ArticleBMC neurology2021
Associations of the neutrophil to lymphocyte ratio with intracranial artery stenosis and ischemic stroke.
Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Elevated neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in peripheral blood are associated with higher risk of atherosclerotic renal artery stenosis.Frontiers in cardiovascular medicine · 2026Article
- Observational
- Predictive Role of Blood Cell-Derived Inflammatory Markers for the Risk of Asymptomatic Cerebral Infarction in Essential Hypertension: A Population-Based Cross-Sectional Study in Central China.Journal of inflammation research · 2025Article
- Association of white matter hyperintensity with systemic inflammation markers and cognitive assessments: a cross-sectional study via SHAP analysis.Frontiers in aging neuroscience · 2025Article
- Association of lymphocyte-to-C-reactive protein ratio with cerebral small vessel disease: a cross-sectional study based on dose-response analysis.Frontiers in neurology · 2024Article
- Prognostic value of inflammation biomarkers for 30-day mortality in critically ill patients with stroke.Frontiers in neurology · 2023Article
- Genetic Polymorphism of NQO1 Gene is Associated with Susceptibility of Ischemic Stroke in Chinese Han Nationality.Neuropsychiatric disease and treatment · 2022Article
- Neutrophil-Related Ratios Predict the 90-Day Outcome in Acute Ischemic Stroke Patients After Intravenous Thrombolysis.Frontiers in physiology · 2021Article
- Neutrophil-to-Lymphocyte Ratio as a Predictive Biomarker for Stroke Severity and Short-Term Prognosis in Acute Ischemic Stroke With Intracranial Atherosclerotic Stenosis.Frontiers in neurology · 2021Article
- Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe neutrophil-to-lymphocyte ratio (NLR) has emerged as an inflammatory marker. However, the associations of NLR with intracranial artery stenosis (ICAS) and ischemic stroke remain unclear. This study aimed to examine the associations of NLR with ICAS and ischemic stroke among a large and high-risk population.
methodsParticipants with records of clinical characteristics were prospectively recruited from the Neurology Department and Health & Physical Examination Center of Qingdao Municipal Hospital. Logistic regression analysis was used to examine the associations of NLR with ICAS and ischemic stroke. Moreover, we also conducted parametric mediation analysis to estimate the effect of NLR on the risk of ischemic stroke mediated through ICAS.
resultsA total of 2989 participants were enrolled in this study. After adjusting for covariates, NLR (OR = 1.125, 95%CI 1.070-1.183) and ICAS (OR = 1.638, 95%CI 1.364-1.967) were significantly associated with ischemic stroke. Compared with the first quartile NLR, the second, third and fourth quartiles NLR were independent risk predictors for ischemic stroke (P for trend < 0.001); the third and fourth quartiles were independent predictors for ICAS (P for trend < 0.001). The mediation analysis showed that ICAS partially mediated the association between NLR and ischemic stroke, accounting for 14.4% of the total effect (P < 0.001).
conclusionsNLR was significantly associated with ICAS and ischemic stroke. Besides, ICAS partially mediated the association between NLR and ischemic stroke.
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