Evidence map›Paper›PMID 33546645›Full record

ArticleBMC pediatrics2021

Analysis of clinical characteristics of severe pertussis in infants and children: a retrospective study.

Caiying Wang, Huimin Zhang, Yanlan Zhang, Lin Xu, Min Miao, Hongling Yang, Yuhuan Liu, Shuxin He, Lin Pang

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In one paragraph

Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Whooping cough hospitalisations among patients with chronic conditions: a retrospective analysis of incidence and costs, France, 2008 to 2020.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caiying WangDepartment of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Huimin ZhangDepartment of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Yanlan ZhangDepartment of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Lin XuDepartment of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Min MiaoDepartment of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Hongling YangDepartment of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Yuhuan LiuDepartment of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Shuxin HeDepartment of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Lin PangDepartment of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China. panglin306@sina.com.

Funding

Beijing Ditan Hospital of Capital Medical University 2209-25-111
6 · The paper itself

Abstract

backgroundThe incidence of pertussis shows an increasing trend in recent years, but some clinicians often lack sufficient understanding of the clinical characteristics and risk factors for severe pertussis, and more effective measures should be taken to reduce the incidence and mortality of pertussis in young infants

methodsA retrospective study was conducted, and 184 infants and children with pertussis who had been hospitalized in the Department of Pediatrics of Beijing Ditan Hospital affiliated with Capital Medical University from January 2016 to December 2017 were included. Clinical data of the patients were collected and the clinical characteristics were statistically analyzed

resultsAmong the 184 patients, 41.85% were infants < 3 months of age, and 65.22% of the total patients were not vaccinated against pertussis. There were 22 critically ill children, among whom 4 died, and compared with mild cases, they had a higher proportion of children younger than 3 months of age and infants not vaccinated against pertussis (63.64% vs. 38.89% and 100% vs. 60.49%, respectively); a higher proportion of children with severe pneumonia (100% vs. 0%); higher leukocyte count(× 109/L , 35.80 ± 20.53 vs 19.41 ± 8.59); and a higher proportion of children with severe hyperleukocytosis (18.18% vs. 0%, respectively) (P<0.05)

conclusions1. Infants aged <3 months not vaccinated for pertussis appear more likely to become infected and have more severe disease. 2. Severe pneumonia and hyperleukocytosis are the main mechanisms underlying severe pertussis.

Indexed as

PneumoniaWhooping CoughAgedChildHumansIncidenceInfantRetrospective StudiesRisk Factorsclinical characteristicshyperleukocytosispertussissevere pneumonia

Identifiers

PMID33546645
PMCPMC7863367

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.