SynthesisBMC pregnancy and childbirth2021
Haemostatic and thrombo-embolic complications in pregnant women with COVID-19: a systematic review and critical analysis.
Synthesis in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Thromboembolic risk in pregnant women with SARS-CoV-2 infection - A systematic review.Taiwanese journal of obstetrics & gynecology · 2022Pooled it
- Diagnostic challenges for severe infection with severe acute respiratory syndrome coronavirus 2 in pregnancy: a case report.Journal of medical case reports · 2025Article
- SARS-CoV-2 infection in pregnant women and incidence of thromboembolic disease: an analysis of the Covid-19-Related Obstetric and Neonatal Outcome Study (CRONOS) in Germany.Archives of gynecology and obstetrics · 2025Observational
- Impact of Omicron BA.5 infection on maternal and neonatal outcomes.Frontiers in cellular and infection microbiology · 2025Article
- Prevalence of Thrombocytopenia in Pregnant Women with COVID-19: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Assessing the Impact of Hematological Changes in Pregnancy on Maternal and Fetal Death: A Narrative Review.Cureus · 2024Review
- COVID-19 complicating pregnancy: A retrospective study of nine intensive care unit patients.Obstetric medicine · 2024Article
- Evaluation of the Relationship between Early Clinical Manifestations and Changes in Biochemical, Inflammatory, and Coagulation Parameters and the Prognosis of Pregnant Women with COVID-19 Admitted to the ICU.Advanced biomedical research · 2024Article
- Hematologic characteristics and coagulopathy in pregnancy with COVID-19 succeeding the first wave: a multicenter retrospective cross-sectional study.Research and practice in thrombosis and haemostasis · 2024Article
- Amniotic fluid pulmonary embolism and COVID-19: Case report.Radiology case reports · 2023Article
- Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review.Biomedicines · 2023Review
- Coronavirus Disease-2019 in Pregnancy.Clinics in chest medicine · 2023Review
- SARS-CoV-2 in Pregnancy, Birth and Puerperium. Guideline of the DGGG and DGPM (S2k-Level, AWMF Registry Number 015/092, March 2022).Geburtshilfe und Frauenheilkunde · 2023Article
- Association of Pre-Pregnancy Obesity and COVID-19 with Poor Pregnancy Outcome.Journal of clinical medicine · 2023Article
- COVID-19 Therapeutics and Considerations for Pregnancy.Obstetrics and gynecology clinics of North America · 2023Review
- A neonatal case of cerebral venous sinus thrombosis with intrauterine onset after COVID-19 infection during pregnancy: Cause or coincidence?Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023Article
- Thromboprophylaxis in Pregnant Women with COVID-19: An Unsolved Issue.International journal of environmental research and public health · 2023Review
- Functional consequences of SARS-CoV-2 infection in pregnant women, fetoplacental unit, and neonate.Biochimica et biophysica acta. Molecular basis of disease · 2023Review
- Effects of Biological Sex and Pregnancy on SARS-CoV-2 Pathogenesis and Vaccine Outcomes.Current topics in microbiology and immunology · 2023Article
- Maternal and Neonatal Outcomes of COVID-19 Infection in Pregnancy.Archives of Iranian medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs pregnancy is a physiological prothrombotic state, pregnant women may be at increased risk of developing coagulopathic and/or thromboembolic complications associated with COVID-19.
methodsTwo biomedical databases were searched between September 2019 and June 2020 for case reports and series of pregnant women with a diagnosis of COVID-19 based either on a positive swab or high clinical suspicion where no swab had been performed. Additional registry cases known to the authors were included. Steps were taken to minimise duplicate patients. Information on coagulopathy based on abnormal coagulation test results or clinical evidence of disseminated intravascular coagulation (DIC), and on arterial or venous thrombosis, were extracted using a standard form. If available, detailed laboratory results and information on maternal outcomes were analysed.
resultsOne thousand sixty-three women met the inclusion criteria, of which three (0.28, 95% CI 0.0 to 0.6) had arterial and/or venous thrombosis, seven (0.66, 95% CI 0.17 to 1.1) had DIC, and a further three (0.28, 95% CI 0.0 to 0.6) had coagulopathy without meeting the definition of DIC. Five hundred and thirty-seven women (56%) had been reported as having given birth and 426 (40%) as having an ongoing pregnancy. There were 17 (1.6, 95% CI 0.85 to 2.3) maternal deaths in which DIC was reported as a factor in two.
conclusionsOur data suggests that coagulopathy and thromboembolism are both increased in pregnancies affected by COVID-19. Detection of the former may be useful in the identification of women at risk of deterioration.
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Registered trials
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