Evidence map›Paper›PMID 33546583›Full record

ArticleThe journal of physiological sciences : JPS2021

The activation of galanin receptor 2 plays an antinociceptive effect in nucleus accumbens of rats with neuropathic pain.

Yan Dong, Chong-Yang Li, Xiao-Min Zhang, Ya-Nan Liu, Shuang Yang, Meng-Nan Li, Shi-Lian Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yan Dong *Department of Physiology, School of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, China.
Chong-Yang Li *Department of Oncology, Affiliated Hospital, Yunnan University, Kunming, Yunnan, China.
Xiao-Min Zhang *Department of Physiology, School of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, China.
Ya-Nan LiuDepartment of Physiology, School of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, China.
Shuang YangDepartment of Physiology, School of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, China.
Meng-Nan LiDepartment of Physiology, School of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, China.
Shi-Lian XuDepartment of Physiology, School of Basic Medicine, Kunming Medical University, Kunming, 650500, Yunnan, China. xushilian@kmmu.edu.cn.
Kunming Medical University · CNYunnan University · CN

Funding

National Natural Science Foundation of China NSFC 31960168National Natural Science Foundation of China (CN) NSFC 31360245
6 · The paper itself

Abstract

Our previous research has shown that galanin plays an antinociceptive effect via binding to galanin receptors (GalRs) in nucleus accumbens (NAc). This study focused on the involvement of GalR2 in galanin-induced antinociceptive effect in NAc of neuropathic pain rats. The chronic constriction injury of sciatic nerve (CCI) was used to mimic neuropathic pain model. The hind paw withdrawal latency (HWL) to thermal stimulation and hind paw withdrawal threshold (HWT) to mechanical stimulation were measured as the indicators of pain threshold. The results showed that 14 and 28 days after CCI, the expression of GalR2 was up-regulated in bilateral NAc of rats, and intra-NAc injection of GalR2 antagonist M871 reversed galanin-induced increases in HWL and HWT of CCI rats. Furthermore, intra-NAc injection of GalR2 agonist M1145 induced increases in HWL and HWT at day 14 and day 28 after CCI, which could also be reversed by M871. Finally, we found that M1145-induced antinociceptive effect in NAc of CCI rats was stronger than that in intact rats. These results imply that the GalR2 is activated in the NAc from day 14 to day 28 after CCI and GalR2 is involved in the galanin-induced antinociceptive effect in NAc of CCI rats.

Indexed as

AnimalsGalaninGene Expression RegulationMaleNeuralgiaNucleus AccumbensPeptidesRatsRats, Sprague-DawleyReceptor, Galanin, Type 2Sciatic NeuropathyGalaninM1145 peptideM871 peptidePeptidesReceptor, Galanin, Type 2Antinociceptive effectGalaninGalR2Neuropathic painNucleus accumbens

Identifiers

PMID33546583
PMCPMC10717428
OpenAlexW3127664400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.