Evidence map›Paper›PMID 33546433›Full record

ArticleCancers2021

Deuterium Oxide (D

Jana Jandova, Anh B Hua, Jocelyn Fimbres, Georg T Wondrak

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. The analgesic potential of heavy water.Nature biomedical engineering · 2025
    Article
  3. DThe journal of physical chemistry. B · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jana JandovaDepartment of Pharmacology and Toxicology, College of Pharmacy & UA Cancer Center, University of Arizona, Tucson, AZ 85724, USA.
Anh B HuaDepartment of Pharmacology and Toxicology, College of Pharmacy & UA Cancer Center, University of Arizona, Tucson, AZ 85724, USA.
Jocelyn FimbresDepartment of Pharmacology and Toxicology, College of Pharmacy & UA Cancer Center, University of Arizona, Tucson, AZ 85724, USA.
Georg T WondrakDepartment of Pharmacology and Toxicology, College of Pharmacy & UA Cancer Center, University of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0003-4799-8608
University of Arizona · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Targeted Prevention for Non-Melanoma Skin CancerP01CA229112 · NCI · UNIVERSITY OF ARIZONA · PI MANSOUR, HEIDI M. · 2019 to 2023
$7.1M
Repurposing Clinical ACT Antimalarials for Experimental Melanoma InterventionR01CA229418 · NCI · UNIVERSITY OF ARIZONA · PI WONDRAK, GEORG T · 2019 to 2023
$1.7M
Graduate Industrial Hygiene Training Program Grant, University of ArizonaT03OH009631 · OH · UNIVERSITY OF ARIZONA · PI BURGESS, JEFFEREY L. · 2012 to 2025
$1.5M
Exploring the role of HOCI in skin photodamage, immunosuppression, and carcinogenesisR21ES029579 · NIEHS · UNIVERSITY OF ARIZONA · PI WONDRAK, GEORG T · 2019 to 2020
$409k
Zinc dysregulation as a druggable target in human skin photocarcinogenesisR03CA230949 · NCI · UNIVERSITY OF ARIZONA · PI WONDRAK, GEORG T · 2018 to 2019
$147k
NCI NIH HHS P01 CA229112NCI NIH HHS R01 CA229418NCI NIH HHS R03 CA230949NIEHS NIH HHS P30 ES006694NIEHS NIH HHS R21 ES029579NIH HHS CA023074NIH HHS ES006694NIH HHS ES007091NIH HHS P01CA229112NIH HHS R01CA229418NIH HHS R03CA230949NIH HHS R21ES029579NIOSH CDC HHS T03 OH009631
6 · The paper itself

Abstract

There are two stable isotopes of hydrogen, protium (

Indexed as

A375-luciferase reporter cellsA375 melanoma xenograft modelcellular stress responsedeuterium oxideheavy watermalignant melanomaSCID mouse metastasis modeltranswell invasion

Identifiers

PMID33546433
PMCPMC7913703
OpenAlexW3128804109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.