Evidence map›Paper›PMID 33546327›Full record

ArticleBiomedicines2021

Unraveling Molecular Pathways Altered in MeCP2-Related Syndromes, in the Search for New Potential Avenues for Therapy.

Alba-Aina Castells, Rafel Balada, Alba Tristán-Noguero, Mar O'Callaghan, Elisenda Cortès-Saladelafont, Ainhoa Pascual-Alonso, Àngels Garcia-Cazorla, Judith Armstrong, Soledad Alcántara

Abstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alba-Aina CastellsNeural Development Lab, Departament de Patologia i Terapèutica Experimental, Institut de Neurociències, Universitat de Barcelona, l'Hospitalet de Llobregat, 08907 Barcelona, Spain.ORCID 0000-0002-3508-8562
Rafel BaladaNeural Development Lab, Departament de Patologia i Terapèutica Experimental, Institut de Neurociències, Universitat de Barcelona, l'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Alba Tristán-NogueroDepartments of Neurology, Biochemistry and Genetics, Institut Pediàtric de Recerca, CIBERER and ISCIII, Hospital San Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
Mar O'CallaghanDepartments of Neurology, Biochemistry and Genetics, Institut Pediàtric de Recerca, CIBERER and ISCIII, Hospital San Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.ORCID 0000-0002-1896-1622
Elisenda Cortès-SaladelafontDepartments of Neurology, Biochemistry and Genetics, Institut Pediàtric de Recerca, CIBERER and ISCIII, Hospital San Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
Ainhoa Pascual-AlonsoDepartments of Neurology, Biochemistry and Genetics, Institut Pediàtric de Recerca, CIBERER and ISCIII, Hospital San Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
Àngels Garcia-CazorlaDepartments of Neurology, Biochemistry and Genetics, Institut Pediàtric de Recerca, CIBERER and ISCIII, Hospital San Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
Judith ArmstrongDepartments of Neurology, Biochemistry and Genetics, Institut Pediàtric de Recerca, CIBERER and ISCIII, Hospital San Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.ORCID 0000-0003-0588-9307
Soledad AlcántaraNeural Development Lab, Departament de Patologia i Terapèutica Experimental, Institut de Neurociències, Universitat de Barcelona, l'Hospitalet de Llobregat, 08907 Barcelona, Spain.ORCID 0000-0003-3313-2715

Funding

Instituto de Salud Carlos III PI15/01082
6 · The paper itself

Abstract

Methyl-CpG-binding protein 2 (MeCP2) is an X-linked epigenetic modulator whose dosage is critical for neural development and function. Loss-of-function mutations in

Indexed as

MeCP2MECP2 duplication syndromemicrocephalymiRNA biomarkersRett syndrome

Identifiers

PMID33546327
PMCPMC7913493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.