Evidence map›Paper›PMID 33546266›Full record

ReviewDiagnostics (Basel, Switzerland)2021

The Effect of Non-Invasive Brain Stimulation (NIBS) on Attention and Memory Function in Stroke Rehabilitation Patients: A Systematic Review and Meta-Analysis.

Takatoshi Hara, Aturan Shanmugalingam, Amanda McIntyre, Amer M Burhan

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05814588 (Effects of Anodal Transcranial Direct Current Stimulation on Cognition in Subacute Stroke), which is not on this map. Cited by 49 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 15 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05814588 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Anodal Transcranial Direct Current Stimulation on Cognition in Subacute Stroke

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled56ConditionsStrokeArmsAnodal TDCS, Sham Anodal TDCS
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 15 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. TMS and tDCS as potential tools for the treatment of cognitive deficits in Parkinson's disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Combined noninvasive brain stimulation virtual reality for upper limb rehabilitation poststroke: A systematic review of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Effect of non-invasive brain stimulation on conscious disorder in patients after brain injury: a network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Pooled it
  12. Pooled it
  13. Guideline
  14. Pooled it
  15. Pooled it
  16. rTMS Over Dorsolateral Prefrontal Cortex Augments Dual-Task Training for Mobility, Balance and Cognition in Sub-Acute Stroke: A Randomized Controlled Trial.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
    Trial
  17. Trial
  18. Trial
  19. Trial
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Takatoshi HaraDepartment of Rehabilitation Medicine, School of Medicine, Jikei University, Tokyo 105-8461, Japan.ORCID 0000-0002-4153-168X
Aturan ShanmugalingamSt. Joseph's Health Care, Parkwood Institute Mental Health, London, ON N6A 4V2, Canada.ORCID 0000-0003-1685-4177
Amanda McIntyreParkwood Institute Research, Parkwood Institute, London, ON N6C 0A7, Canada.
Amer M BurhanParkwood Institute Research, Parkwood Institute, London, ON N6C 0A7, Canada.ORCID 0000-0002-9888-008X
Western University · CAJikei University School of Medicine · JPParkwood Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn recent years, the potential of non-invasive brain stimulation (NIBS) for therapeutic effects on cognitive functions has been explored for populations with stroke. There are various NIBS methods depending on the stimulation site and stimulation parameters. However, there is no systematic NIBS review of post-stroke cognitive impairment with a focus on stimulation sites and stimulation parameters. The purpose of this study is to conduct a systematic review and meta-analysis on effectiveness and safety of NIBS for cognitive impairment after a stroke to obtain new insights. This study was prospectively registered with the PROSPERO database of systematic reviews (CRD42020183298).

methodsAll English articles from MEDLINE, Scopus, CINAHL, Embase, PsycINFO, and CENTRAL were searched from inception up to 31 December 2020. Randomized and prospective controlled trials were included for the analysis. Studies with at least five individuals post-stroke, whereby at least five sessions of NIBS were provided and using standardized neuropsychological measurement of cognition, were included. We assessed the methodological quality of selected studies as described in the Physiotherapy Evidence Database (PEDro) scoring system.

resultsA total of 10 studies met eligibility criteria. Six studies used repetitive transcranial magnetic stimulation (rTMS) and four studies used transcranial direct current stimulation (tDCS). The pooled sample size was 221 and 196 individuals who received rTMS and tDCS respectively. Eight studies combined general rehabilitation, cognitive training, or additional therapy with NIBS. In rTMS studies, target symptoms included global cognition (

conclusionsIn post-stroke patients with deficits in cognitive function, including attention, memory, and WM, NIBS shows promising positive effects. However, this effect is limited, suggesting that further studies are needed with more precision in stimulation sites and stimulation parameters. Future studies using advanced neurophysiological and neuroimaging tools to allow for a network-based approach to treat cognitive symptoms post-stroke with NIBS are warranted.

Indexed as

non-invasive brain stimulationstroketranscranial direct current stimulationtranscranial magnetic stimulation

Identifiers

PMID33546266
PMCPMC7913379
OpenAlexW3126283921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.