Evidence map›Paper›PMID 33546180›Full record

ArticleMicroorganisms2021

Exploring the Chemical Space of Macro- and Micro-Algae Using Comparative Metabolomics.

Alison H Hughes, Florent Magot, Ahmed F Tawfike, Cecilia Rad-Menéndez, Naomi Thomas, Louise C Young, Laura Stucchi, Daniele Carettoni, Michele S Stanley, RuAngelie Edrada-Ebel and 1 more

Abstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Application ofMetabolites · 2023
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alison H HughesStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.ORCID 0000-0002-9670-0663
Florent MagotStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.
Ahmed F TawfikeStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.ORCID 0000-0003-2061-3093
Cecilia Rad-MenéndezScottish Association for Marine Science, Scottish Marine Institute, Oban PA37 1QA, UK.ORCID 0000-0001-5248-0948
Naomi ThomasScottish Association for Marine Science, Scottish Marine Institute, Oban PA37 1QA, UK.
Louise C YoungStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.
Laura StucchiAxxam SpA, Openzone, Bresso, 20091 Milan, Italy.
Daniele CarettoniAxxam SpA, Openzone, Bresso, 20091 Milan, Italy.
Michele S StanleyScottish Association for Marine Science, Scottish Marine Institute, Oban PA37 1QA, UK.
RuAngelie Edrada-EbelStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.
Katherine R DuncanStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.ORCID 0000-0002-3670-4849

Funding

Industrial Biotechnology Innovation Centre PhD studentshipSeventh Framework Programme 311932
6 · The paper itself

Abstract

With more than 156,000 described species, eukaryotic algae (both macro- and micro-algae) are a rich source of biological diversity, however their chemical diversity remains largely unexplored. Specialised metabolites with promising biological activities have been widely reported for seaweeds, and more recently extracts from microalgae have exhibited activity in anticancer, antimicrobial, and antioxidant screens. However, we are still missing critical information on the distinction of chemical profiles between macro- and microalgae, as well as the chemical space these metabolites cover. This study has used an untargeted comparative metabolomics approach to explore the chemical diversity of seven seaweeds and 36 microalgal strains. A total of 1390 liquid chromatography-mass spectrometry (LC-MS) features were detected, representing small organic algal metabolites, with no overlap between the seaweeds and microalgae. An in-depth analysis of four

Indexed as

bioactivitybiotechnologycomparative metabolomicsmass spectrometrymicroalgaemicroalgal metabolites

Identifiers

PMID33546180
PMCPMC7913273

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.