Evidence map›Paper›PMID 33546160›Full record

ArticleJournal of clinical medicine2021

Intrahematomal Ultrasound Enhances RtPA-Fibrinolysis in a Porcine Model of Intracerebral Hemorrhage.

Julia Masomi-Bornwasser, Axel Heimann, Christian Schneider, Tristan Klodt, Hammoud Elmehdawi, Andrea Kronfeld, Harald Krenzlin, Yasemin Tanyildizi, Karl-Friedrich Kreitner, Oliver Kempski and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Julia Masomi-BornwasserDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.ORCID 0000-0003-1955-9827
Axel HeimannInstitute for Neurosurgical Pathophysiology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.ORCID 0000-0003-2510-3228
Christian SchneiderDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Tristan KlodtInstitute of Neuropathology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Hammoud ElmehdawiDepartment of Neuroradiology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Andrea KronfeldDepartment of Neuroradiology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.ORCID 0000-0003-1814-5649
Harald KrenzlinDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Yasemin TanyildiziDepartment of Neuroradiology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Karl-Friedrich KreitnerDepartment of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Oliver KempskiInstitute for Neurosurgical Pathophysiology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Clemens SommerInstitute of Neuropathology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Florian RingelDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.ORCID 0000-0003-3132-7543
Naureen KericDepartment of Neurosurgery, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Johannes Gutenberg University Mainz · DE

Funding

German Society of Neuro-Intensive Care and Emergency Medicine (Deutsche Gesellschaft für NeuroIntensiv- und Notfallmedizin; DGNI) nn
6 · The paper itself

Abstract

Catheter-based ultrasound-thrombolysis has been successfully used in a small clinical trial in order to enhance recombinant tissue plasminogen activator (rtPA)-fibrinolysis, for the treatment of spontaneous intracerebral hemorrhages (ICHs). The aim of this study was to investigate the ultra-early effects of ultrasound on hematoma and the surrounding brain tissue in a porcine ICH-model. To achieve this, 21 pigs with a right frontal ICH were randomly assigned to four groups: (1) drainage (

Indexed as

intracerebral hemorrhageminimally invasive therapyrtPA-fibrinolysisultrasound-thrombolysis

Identifiers

PMID33546160
PMCPMC7913235
OpenAlexW3127460174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.