Evidence map›Paper›PMID 33546125›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies.

Anna Mueller-Schoell, Lena Klopp-Schulze, Robin Michelet, Madelé van Dyk, Thomas E Mürdter, Matthias Schwab, Markus Joerger, Wilhelm Huisinga, Gerd Mikus, Charlotte Kloft

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Anna Mueller-SchoellDepartment of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 14163 Berlin, Germany.ORCID 0000-0002-5936-1877
Lena Klopp-SchulzeDepartment of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 14163 Berlin, Germany.
Robin MicheletDepartment of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 14163 Berlin, Germany.ORCID 0000-0002-5485-607X
Madelé van DykCollege of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia.
Thomas E MürdterDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University Tübingen, 70376 Tübingen, Germany.
Matthias SchwabDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.
Markus JoergerDepartment of Medical Oncology and Hematology, Cantonal Hospital, 9007 St. Gallen, Switzerland.ORCID 0000-0001-6602-6287
Wilhelm HuisingaInstitute of Mathematics, University of Potsdam, 14476 Potsdam, Germany.
Gerd MikusDepartment of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 14163 Berlin, Germany.
Charlotte KloftDepartment of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 14163 Berlin, Germany.
Freie Universität Berlin · DEDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology · DEFlinders University · AUGerman Cancer Research Center · DEKantonsspital St. Gallen · CHUniversity of Potsdam · DE

Funding

Freie Universität Berlin Open Access Fund
6 · The paper itself

Abstract

Tamoxifen is widely used in breast cancer treatment and minimum steady-state concentrations of its active metabolite endoxifen (C

Indexed as

model-informed precision dosingnon-adherencepharmacokineticspharmacometricstamoxifen

Identifiers

PMID33546125
PMCPMC7913149
OpenAlexW3127131185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.