ReviewJournal of clinical medicine2021
Childhood-Onset Systemic Lupus Erythematosus: Southeast Asian Perspectives.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Management and outcomes in children with lupus nephritis in the developing countries.Pediatric nephrology (Berlin, Germany) · 2023Pooled it
- Clinicopathological Spectrum of Pediatric Renal Biopsies: A Retrospective Observational Study From South India.Cureus · 2026Article
- Pathogenesis, Treatment Advances, and Renal Outcomes in Childhood-Onset Lupus Nephritis.Clinical pediatrics · 2026Review
- Epidemiology and prognosis of childhood lupus nephritis in the Afro-descendant population of the French Overseas Departments of America.BMC nephrology · 2026Article
- Vitamin D deficiency in newly diagnosed childhood-onset systemic lupus erythematosus: prevalence and clinical associations.European journal of pediatrics · 2026Article
- Correlation Between Systemic Inflammation Response Index and Systemic Immune-Inflammation Index and Disease Activity of Lupus Nephritis in Children.Children (Basel, Switzerland) · 2026Article
- Effectiveness of IV cyclophosphamide and mycophenolate mofetil in the treatment of childhood-onset lupus nephritis in a resource-limited setting.BMC rheumatology · 2026Article
- Impact of high disease activity on damage accrual and disease outcomes in childhood-onset systemic lupus erythematosus.Frontiers in pediatrics · 2026Article
- Childhood-onset systemic lupus erythematosus presenting with growth retardation and delayed puberty: a case report.Frontiers in pediatrics · 2026Article
- Incidence and risk factors of herpes zoster infection in pediatric systemic lupus erythematosus.Pediatric rheumatology online journal · 2025Article
- Prognostic factors for disease progression and mortality of childhood-onset lupus nephritis in the Philippines: a retrospective cohort study in a tertiary hospital.Pediatric rheumatology online journal · 2025Article
- Lymphopenia as an Independent Marker of Disease Activity in Children with Systemic Lupus Erythematosus.Children (Basel, Switzerland) · 2025Article
- Childhood-Onset Systemic Lupus Erythematosus (cSLE): An International Perspective.Current allergy and asthma reports · 2024Review
- Case Report: Diagnostic itinerary of a male case of juvenile-onset systemic lupus erythematosus in Bouake.Frontiers in pediatrics · 2024Article
- Article
- An eight-year old girl with fever and rash: What is the possible diagnosis?Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2023Article
- Case report: Aseptic splenic abscesses in childhood-onset systemic lupus erythematosus.Frontiers in pediatrics · 2023Article
- Clinical and histopathological study of renal biopsy in Nepalese children: A single center experience.PloS one · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood onset systemic lupus erythematosus is a rare disease that is more common amongst Southeast Asian children compared to the West. It is typified by a peripubertal onset and a female preponderance, which increases with advancing age. Organs commonly involved at diagnosis include haematological, renal, and mucocutaneous. Fever, malar rash, and cutaneous vasculitis are common. Lupus nephritis is typically proliferative especially Class IV and contributes to both disease activity and damage. Antinuclear antibody and anti-dsDNA positivity are both prevalent in this region. Disease activity is higher than Western cohorts at onset but responds to therapy reducing to low disease activity by six months. However, organ damage occurs early and continues to accumulate over the time, a consequence of both active disease (neurological and renal systems) and steroid-related complications especially in the eye (cataract and glaucoma) and musculoskeletal systems (avascular necrosis). Infections remain the leading cause of death and mortality in this region is highly variable contributed by the heterogeneity in social economic status, healthcare access, and availability of paediatric rheumatology expertise in the region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.