Evidence map›Paper›PMID 33545890›Full record

ReviewMaterials science & engineering. C, Materials for biological applications2021

Osteogenic differentiation cues of the bone morphogenetic protein-9 (BMP-9) and its recent advances in bone tissue regeneration.

Angshuman Bharadwaz, Ambalangodage C Jayasuriya

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials science & engineering. C, Materials for biological applications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Initial fracture gap distance as a potential quantitative predictor for atlas fracture nonunion: A preliminary retrospective analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  12. [Application progress of collagen membranes in oral medicine].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Angshuman BharadwazBiomedical Engineering Program, Department of Bioengineering, College of Engineering, The University of Toledo, Toledo, OH, USA.
Ambalangodage C JayasuriyaBiomedical Engineering Program, Department of Bioengineering, College of Engineering, The University of Toledo, Toledo, OH, USA; Department of Orthopaedic Surgery, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA. Electronic address: a.jayasuriya@utoledo.edu.
University of Toledo · US

Funding

Multifunctional bone putty for craniomaxillofacial bone repairR01DE023356 · NIDCR · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI JAYASURIYA, AMBALANGODAGE CHAMPA · 2013 to 2017
$2.0M
NIDCR NIH HHS R01 DE023356
6 · The paper itself

Abstract

Bone regeneration using bioactive molecules and biocompatible materials is growing steadily with the advent of the new findings in cellular signaling. Bone Morphogenetic Protein (BMP)-9 is a considerably recent discovery from the BMP family that delivers numerous benefits in osteogenesis. The Smad cellular signaling pathway triggered by BMPs is often inhibited by Noggin. However, BMP-9 is resistant to Noggin, thus, facilitating a more robust cellular differentiation of osteoprogenitor cells into preosteoblasts and osteoblasts. This review encompasses a general understanding of the Smad signaling pathway activated by the BMP-9 ligand molecule with its specific receptors. The robust osteogenic cellular differentiation cue provided by BMP-9 has been reviewed from a bone regeneration perspective with several in vitro as well as in vivo studies reporting promising results for future research. The effect of the biomaterial, chosen in such studies as the scaffold or carrier matrix, on the activity of BMP-9 and subsequent bone regeneration has been highlighted in this review. The non-viral delivery technique for BMP-9 induced bone regeneration is a safer alternative to its viral counterpart. The recent advances in non-viral BMP-9 delivery have also highlighted the efficacy of the protein molecule at a low dosage. This opens a new horizon as a more efficient and safer alternative to BMP-2, which was prevalent among clinical trials; however, BMP-2 applications have reported its downsides during bone defect healing such as cystic bone formation.

Indexed as

Growth Differentiation Factor 2OsteogenesisBone Morphogenetic Protein 2Bone Morphogenetic ProteinsBone RegenerationCell DifferentiationCuesOsteoblastsBone Morphogenetic Protein 2Bone Morphogenetic ProteinsGrowth Differentiation Factor 2Bone morphogenetic protein (BMP)Bone regenerationCell signalingNon-viral deliveryScaffoldSmad

Identifiers

PMID33545890
PMCPMC7867678
OpenAlexW3108310482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.