Evidence map›Paper›PMID 33545868›Full record

ArticleMaterials science & engineering. C, Materials for biological applications2021

Microfluidics generation of chitosan microgels containing glycerylphytate crosslinker for in situ human mesenchymal stem cells encapsulation.

Ana Mora-Boza, Lina M Mancipe Castro, Rebecca S Schneider, Woojin M Han, Andrés J García, Blanca Vázquez-Lasa, Julio San Román

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials science & engineering. C, Materials for biological applications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Gelatin maleimide microgels for hematopoietic progenitor cell encapsulation.Journal of biomedical materials research. Part A · 2024
    Article
  3. Recent developments in chitosan based microgels and their hybrids.International journal of biological macromolecules · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ana Mora-BozaInstitute of Polymer Science and Technology (ICTP-CSIC), Madrid, Spain; CIBER-BBN, Health Institute Carlos III, Madrid, Spain.
Lina M Mancipe CastroWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
Rebecca S SchneiderPetit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Woojin M HanWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
Andrés J GarcíaWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
Blanca Vázquez-LasaInstitute of Polymer Science and Technology (ICTP-CSIC), Madrid, Spain; CIBER-BBN, Health Institute Carlos III, Madrid, Spain. Electronic address: bvazquez@ictp.csic.es.
Julio San RománInstitute of Polymer Science and Technology (ICTP-CSIC), Madrid, Spain; CIBER-BBN, Health Institute Carlos III, Madrid, Spain.
Georgia Institute of Technology · USBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESInstituto de Salud Carlos III · ES

Funding

Hydrogels for hMSC delivery & engraftmentR01AR062368 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 2012 to 2022
$3.5M
Osseo-reparative, integrin-specific materialsR01AR062920 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 2012 to 2021
$3.2M
IVIS Spectrum in vivo Imaging SystemS10OD016264 · OD · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 2015 to 2015
$595k
NIAMS NIH HHS R01 AR062368NIAMS NIH HHS R01 AR062920NIH HHS S10 OD016264
6 · The paper itself

Abstract

Human mesenchymal stem cells (hMSCs) are an attractive source for cell therapies because of their multiple beneficial properties, i.e. via immunomodulation and secretory factors. Microfluidics is particularly attractive for cell encapsulation since it provides a rapid and reproducible methodology for microgel generation of controlled size and simultaneous cell encapsulation. Here, we report the fabrication of hMSC-laden microcarriers based on in situ ionotropic gelation of water-soluble chitosan in a microfluidic device using a combination of an antioxidant glycerylphytate (G

Indexed as

ChitosanMesenchymal Stem CellsMicrogelsAnimalsCell SurvivalHumansMiceMicrofluidicsChitosanMicrogelsChitosan lactateGlycerylphytateHuman mesenchymal stem cells encapsulationMicrofluidicsMicrogelSecretome

Identifiers

PMID33545868
PMCPMC8237249
OpenAlexW3098399966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.