Evidence map›Paper›PMID 33545684›Full record

ArticleJournal of the National Comprehensive Cancer Network : JNCCN2021

Status of the Clinician Investigator in America: An Essential Healthcare Provider Driving Advances in Cancer Care.

Randall F Holcombe, Claire F Verschraegen, Andrew E Chapman, David Gaffney, Richard M Goldberg, Ruben A Mesa, Mohammed Milhem, Martha Mims, Edith P Mitchell, Dan Mulkerin and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the National Comprehensive Cancer Network : JNCCN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. "Brain drain" amongst Israeli physicians who graduated abroad.Israel journal of health policy research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Randall F Holcombe1University of Hawaii Cancer Center, Honolulu, Hawaii.
Claire F Verschraegen2The Ohio State University, Comprehensive Cancer Center, James Cancer Hospital & Solove Research Institute, Columbus, Ohio.
Andrew E Chapman3Sidney Kimmel Cancer Center at Jefferson Health, Philadelphia, Pennsylvania.
David Gaffney4Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
Richard M Goldberg5WVU Cancer Institute, Morgantown, West Virginia.
Ruben A Mesa6Mays Cancer Center, UT Health San Antonio, San Antonio, Texas.
Mohammed Milhem7Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa.
Martha Mims8The Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine, Houston, Texas.
Edith P Mitchell3Sidney Kimmel Cancer Center at Jefferson Health, Philadelphia, Pennsylvania.
Dan Mulkerin9University of Wisconsin Carbone Cancer Center, Madison, Wisconsin; and.
Srinivasan Vijayakumar10University of Mississippi Medical Center Cancer Institute, Jackson, Mississippi.
Sidney Kimmel Cancer Center · USCancer Center of Hawaii · USDan L Duncan Comprehensive Cancer CenterThe Ohio State University · USThe University of Texas Health Science Center at Houston · USUniversity of Iowa · USUniversity of Utah · USUniversity of Wisconsin Carbone Cancer Center · US

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI CHRISTINE M. EISCHEN · 1995 to 2026
$94.8M
NCI NIH HHS P30 CA056036
6 · The paper itself

Abstract

backgroundTranslation of basic discoveries to clinical care for patients with cancer is a difficult process greatly enabled by physician-trained researchers. Three categories of physicians, with responsibilities spanning from laboratory and preclinical research to direct patient care, are involved in the translational research continuum: physician-scientist (PS), clinician investigator (CI), and academic clinician (AC).

methodsTo define how protected time for research efforts is supported, the Association of American Cancer Institutes (AACI) conducted a survey of their member institutions, obtaining 56 responses documenting time spent in research and clinical activities across multiple cancer disciplines, and providing information about funding streams for the different categories of cancer physicians.

resultsResponses showed that PSs and ACs are minimally involved in clinical research activities; the driver or clinical research in academic cancer centers is the CI. A significant concern was a lack of stable funding streams for nonbillable clinical research activities, putting the sustainability of the CI in jeopardy. Limited funding was derived from hospital sources, with most support derived from cancer center sources.

conclusionsThis study highlights the importance of the CI in translational cancer medicine and represents a call to action for institutions and research funding agencies to develop new programs targeted toward CI support to ensure continued progress against cancer.

Indexed as

NeoplasmsPhysiciansResearch PersonnelTranslational Research, BiomedicalHealth PersonnelHumansPatient Care

Identifiers

PMID33545684
PMCPMC9242430
OpenAlexW3127667375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.