Evidence map›Paper›PMID 33545497›Full record

ArticleBiochemical and biophysical research communications2021

Protein-free ribosomal RNA scaffolds can assemble poly-lysine oligos from charged tRNA fragments.

Doris Xu, Yuhong Wang

Abstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. On the Re-Creation of Protoribosome Analogues in the Lab.International journal of molecular sciences · 2024
    Review
  4. Three Biopolymers and Origin of Life Scenarios.Life (Basel, Switzerland) · 2024
    Review
  5. Article
  6. Article
  7. The Origin of Translation: Bridging the Nucleotides and Peptides.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. The Peptidyl Transferase Center: a Window to the Past.Microbiology and molecular biology reviews : MMBR · 2021
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Doris XuDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address: xudo@seas.upenn.edu.
Yuhong WangDepartment of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA. Electronic address: ywang60@uh.edu.

Funding

EF-Tu mutagenesis and functional studyR01GM111452 · NIGMS · UNIVERSITY OF HOUSTON · PI YUHONG WANG, Shoujun Xu · 2015 to 2026
$3.2M
NIGMS NIH HHS R01 GM111452
6 · The paper itself

Abstract

Ribosomal protein synthesis is a central process of the modern biological world. Because the ribosome contains proteins itself, it is very important to understand its precursor and evolution. Small ribozymes have demonstrated the principle of "RNA world" hypothesis, but protein free peptide ligase remains elusive. In this report, we have identified two fragments in the peptidyl transfer center that can synthesize a 9-mer poly-lysine in a solution contains Mg

Indexed as

Protein BiosynthesisHumansLysineModels, MolecularPeptidesPeptidyl TransferasesRibosomesRNA, CatalyticRNA, RibosomalRNA, TransferLysinePeptidesPeptidyl TransferasesRNA, CatalyticRNA, RibosomalRNA, TransferHigh resolution MSLUCA (Last universal common ancestor)Peptide ligasePeptidyl transferase activitySingle molecule FRET

Identifiers

PMID33545497
PMCPMC7936610

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.