Evidence map›Paper›PMID 33545317›Full record

ReviewBehavioural processes2021

Using greenspace and nature exposure as an adjunctive treatment for opioid and substance use disorders: Preliminary evidence and potential mechanisms.

Meredith S Berry, Jillian M Rung, Matthew C Crawford, Ali M Yurasek, Andrea Vásquez Ferreiro, Shahar Almog

Abstract readReview
In one paragraph

Review in Behavioural processes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Community characteristics and substance-free activity and service access predict membership in alcohol use disorder risk profiles.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Place-Based Differences in the Association Between Greenspace and Suicide-Related Outcomes Among Young People.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meredith S BerryDepartment of Health Education and Behavior, University of Florida, Gainesville, FL, USA; Department of Psychology, University of Florida, Gainesville, FL, USA. Electronic address: mberry@ufl.edu.
Jillian M RungDepartment of Psychology, University of Florida, Gainesville, FL, USA; Department of Epidemiology, University of Florida, Gainesville, FL, USA.
Matthew C CrawfordDepartment of Health Education and Behavior, University of Florida, Gainesville, FL, USA.
Ali M YurasekDepartment of Health Education and Behavior, University of Florida, Gainesville, FL, USA.
Andrea Vásquez FerreiroDepartment of Health Education and Behavior, University of Florida, Gainesville, FL, USA.
Shahar AlmogDepartment of Health Education and Behavior, University of Florida, Gainesville, FL, USA.

Funding

UF Substance Abuse Training Center in Public HealthT32DA035167 · NIDA · UNIVERSITY OF FLORIDA · PI Linda B. Cottler · 2014 to 2026
$4.8M
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect DeterminationK01DA052673 · NIDA · UNIVERSITY OF FLORIDA · PI Meredith Berry · 2022 to 2026
$916k
NIDA NIH HHS K01 DA052673NIDA NIH HHS L30 DA052084NIDA NIH HHS T32 DA035167
6 · The paper itself

Abstract

The demand for opioid medication to effectively treat pain has contributed to the surging opioid crisis, which is a major source of morbidity and mortality in the U.S. More than 100,000 people begin opioid maintenance treatment (OMT) annually, the standard pharmacotherapy for opioid use disorder (OUD). Although OMT is the standard care for OUD, patients often experience or develop a heightened sensitivity to pain (hyperalgesia) as a result of the opioid medication, and also have high rates of stress, affective, and anxiety-related conditions. These conditions are interactive with other behavioral and environmental correlates of opioid and other substance use disorders including impulsive decision-making (e.g., harmful opioid use associated with increased delay discounting), and a lack of alternative (i.e., substance-free) and social reinforcement. Collectively these complex and multifaceted factors constitute significant predictors of lack of adherence to OMT (and other pharmacotherapies) and relapse. There is an urgent need, therefore, to develop novel adjunctive treatments that preserve the benefits of OMT and various pharmacotherapies, and simultaneously diminish continued pain and hyperalgesia, reduce stress and anxiety-related conditions, target relevant behavioral mechanism such as impulsive choice, and also serve to enhance the value of alternative and substance free activities. Here, we discuss evidence that an environmental manipulation - access to greenspace and nature - could serve as a potential adjunctive treatment to standard pharmacotherapies by targeting multiple biological and behavioral mechanisms that standard pharmacotherapies do not address.

Indexed as

Analgesics, OpioidOpioid-Related DisordersHumansOpiate Substitution TreatmentParks, RecreationalAnalgesics, OpioidAnxietyCravingDelay discountingGreenspace exposureHyperalgesiaNature exposureOpioidOpioid maintenance treatmentOpioid use disorderPainStressSubstance free rewardSubstance use disorder

Identifiers

PMID33545317
PMCPMC9968503

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.