ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2021
Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: An EMBRACE analysis.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07164534 (A Phase III Trial to Assess the Effectiveness of NRF2 Activator), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase III Trial to Assess the Effectiveness of NRF2 Activator (Oral Sodium-copper- Chlophyllin ) in Locally Advanced Cervical Cancer to Reduce Late Radiotherapy Toxicity. (CHOC-LATE Trial)
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Deep learning in CT image segmentation of cervical cancer: a systematic review and meta-analysis.Radiation oncology (London, England) · 2022Pooled it
- Article
- The impact of uterine position during brachytherapy on treatment outcomes and toxicity in patients with cervical cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Patient stratification for dose scaling in cervical cancer: a model-based analysis using image-guided adaptive brachytherapy.Journal of radiation research · 2026Article
- Surgical interventions for treating vesicovaginal fistula in women.The Cochrane database of systematic reviews · 2026Article
- Insights from plastic and reconstructive surgery wound specialists in managing complex vaginal and vulvar toxicities following radiation therapy.Gynecologic oncology reports · 2025Article
- Comparison of rectal and bladder dose between retractor insertion and gauze packing in intracavitary brachytherapy for cervical cancer.Journal of radiation research · 2025Article
- Preliminary Experience with Electronic Brachytherapy in the Treatment of Locally Advanced Cervical Carcinoma.Cancers · 2025Article
- Exploring the dosimetric advantages of a novel multi-modality radiotherapy platform in prostate cancer.Physical and engineering sciences in medicine · 2025Article
- A simulated annealing-based Bayesian network structure optimization framework for late morbidity prediction with a large prospective dataset.Medical physics · 2025Article
- Impact of radiotherapy on the prognosis in uterine cervical adenocarcinoma: a meta-analysis and retrospective cohort study.Frontiers in oncology · 2025Article
- MRI-based image-guided adaptive brachytherapy for locally advanced cervical cancer in clinical routine: a single-institution experience.Pathology oncology research : POR · 2025Article
- Adaptive brachytherapy for cervical cancer in combined 1.5 T MR/HDR suite: Impact of repeated imaging.Technical innovations & patient support in radiation oncology · 2024Article
- Dose-effect relationship in external beam radiotherapy combined with brachytherapy for cervical cancer: A systematic review.Journal of contemporary brachytherapy · 2024Review
- The effect of physical therapy and mechanical stimulation on dysfunction of lower extremities after total pelvic exenteration in cervical carcinoma patient with rectovesicovaginal fistula induced by radiotherapy: a case report.Journal of medical case reports · 2024Article
- ESGO/ESTRO quality indicators for radiation therapy of cervical cancer.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023Article
- Image-Guided Versus Conventional Brachytherapy for Locally Advanced Cervical Cancer: Experience of Single Institution with the Same Practitioner and Time Period.Cancer research and treatment · 2023Article
- Electronic brachytherapy for gynecological cancers - a systematic review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Review
- Patient-Derived Training Simulator for Image-Guided Adaptive Brachytherapy of Locally Advanced Cervical Cancers: Development and Initial Use.Journal of clinical medicine · 2022Article
- Diagnostic Framework of Pelvic Massive Necrosis with Peritonitis following Chemoradiation for Locally Advanced Cervical Cancer: When Is the Surgery Not Demandable? A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2022Article
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Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify patient- and treatment-related risk factors for fistula, bleeding, cystitis, pain and difficulty in voiding in locally advanced cervical cancer patients treated with radio(chemo)therapy and image-guided adaptive brachytherapy (IGABT). MATERIAL AND
methodsMorbidity within the EMBRACE-I study was prospectively reported for physician-assessed (CTCAE) fistula, bleeding and cystitis and patient-reported (EORTC) pain and difficulty in voiding. Analysis of risk factors was performed in patients without bladder infiltration. Risk factors were tested with Cox regression for grade (G) ≥ 3 cystitis, for G ≥ 2 fistula, bleeding and cystitis, and for EORTC "very much" and "quite a bit" or worse.
resultsOf 1416 patients enrolled, 1153 and 884 patients without bladder infiltration were evaluable for the analysis of CTCAE and EORTC items, respectively. Median follow-up was 48[3-120] months. Crude incidence rates for G ≥ 2 fistula, bleeding and cystitis were 0.7%, 2.7% and 8.8%, respectively, and 16% and 14% for "quite a bit" or worse pain and difficulty in voiding, respectively. Baseline urinary morbidity and overweight/obesity were significant risk factors for most endpoints. Bladder D
conclusionClinical and treatment-related risk factors for bladder fistula, bleeding and cystitis were identified within a prospective and multi-institutional setting. A dose-effect was established with bladder D
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.