Evidence map›Paper›PMID 33545191›Full record

ArticleThe Journal of pediatrics2021

Hepatic Steatosis is Negatively Associated with Bone Mineral Density in Children.

Lauren F Chun, Elizabeth L Yu, Mary Catherine Sawh, Craig Bross, Jeanne Nichols, Lynda Polgreen, Cynthia Knott, Alexandra Schlein, Claude B Sirlin, Michael S Middleton and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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  8. Low T3 Syndrome is Associated with Imbalance of Bone Turnover Biomarker in Patients with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Lauren F ChunDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA.
Elizabeth L YuDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA.
Mary Catherine SawhDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA.
Craig BrossDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA.
Jeanne NicholsDepartment of Family Medicine and Public Health, University of California San Diego, La Jolla, CA; Graduate School of Public Health, San Diego State University, San Diego, CA.
Lynda PolgreenDepartment of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.
Cynthia KnottAltman Clinical and Translational Research Institute, School of Medicine, University of California San Diego School of Medicine, La Jolla, CA.
Alexandra SchleinLiver Imaging Group, Department of Radiology, University of California San Diego School of Medicine, La Jolla, CA.
Claude B SirlinLiver Imaging Group, Department of Radiology, University of California San Diego School of Medicine, La Jolla, CA.
Michael S MiddletonLiver Imaging Group, Department of Radiology, University of California San Diego School of Medicine, La Jolla, CA.
Deborah M KadoDepartment of Family Medicine and Public Health, University of California San Diego, La Jolla, CA; Department of Internal Medicine, University of California San Diego, La Jolla, CA.
Jeffrey B SchwimmerDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA. Electronic address: jschwimmer@health.ucsd.edu.
University of California San Diego · USSan Diego State University · USUCLA Medical Center · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
San Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7M
UC San Diego Clinical and Translational Research InstituteTL1TR001443 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2019
$3.4M
NCATS NIH HHS TL1 TR001443NCATS NIH HHS UL1 TR000100NCATS NIH HHS UL1 TR001442
6 · The paper itself

Abstract

objectiveTo evaluate the relationship between hepatic steatosis and bone mineral density (BMD) in children. In addition, to assess 25-hydroxyvitamin D levels in the relationship between hepatic steatosis and BMD. STUDY

designA community-based sample of 235 children was assessed for hepatic steatosis, BMD, and serum 25-hydroxyvitamin D. Hepatic steatosis was measured by liver magnetic resonance imaging proton density fat fraction (MRI-PDFF). BMD was measured by whole-body dual-energy x-ray absorptiometry.

resultsThe mean age of the study population was 12.5 years (SD 2.5 years). Liver MRI-PDFF ranged from 1.1% to 40.1% with a mean of 9.3% (SD 8.5%). Across this broad spectrum of hepatic fat content, there was a significant negative relationship between liver MRI-PDFF and BMD z score (R = -0.421, P < .001). Across the states of sufficiency, insufficiency, and deficiency, there was a significant negative association between 25-hydroxyvitamin D and liver MRI-PDFF (P < .05); however, there was no significant association between vitamin D status and BMD z score (P = .94). Finally, children with clinically low BMD z scores were found to have higher alanine aminotransferase (P < .05) and gamma-glutamyl transferase (P < .05) levels compared with children with normal BMD z scores.

conclusionsAcross the full range of liver MRI-PDFF, there was a strong negative relationship between hepatic steatosis and BMD z score. Given the prevalence of nonalcoholic fatty liver disease and the critical importance of childhood bone mineralization in protecting against osteoporosis, clinicians should prioritize supporting bone development in children with nonalcoholic fatty liver disease.

Indexed as

Absorptiometry, PhotonAdolescentAlanine TransaminaseBone DensityChildFemalegamma-GlutamyltransferaseHumansLiverMagnetic Resonance ImagingMaleNon-alcoholic Fatty Liver DiseaseSampling StudiesVitamin D25-hydroxyvitamin DAlanine Transaminasegamma-GlutamyltransferaseVitamin DMRI-PDFFNAFLDosteopeniaosteoporosispediatricvitamin D

Identifiers

PMID33545191
PMCPMC8154638
OpenAlexW3128088113

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.