Evidence map›Paper›PMID 33545173›Full record

ArticleThe Journal of biological chemistry

Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206.

Hadar Feinberg, Sabine A F Jégouzo, Yi Lasanajak, David F Smith, Kurt Drickamer, William I Weis, Maureen E Taylor

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. The Scavenger Function of LSECs, a Regulator of Liver Diseases.Current issues in molecular biology · 2026
    Review
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  6. Article
  7. Review
  8. Article
  9. Review
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  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
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  17. Article
  18. GCI-Based Affinity Screening of Synthetic Oligomannosides toward Concanavalin A.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hadar FeinbergDepartments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA.
Sabine A F JégouzoDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Yi LasanajakEmory Comprehensive Glycomics Core, Emory University School of Medicine, Atlanta, Georgia, USA.
David F SmithEmory Comprehensive Glycomics Core, Emory University School of Medicine, Atlanta, Georgia, USA.
Kurt DrickamerDepartment of Life Sciences, Imperial College London, London, United Kingdom.
William I WeisDepartments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA. Electronic address: bill.weis@stanford.edu.
Maureen E TaylorDepartment of Life Sciences, Imperial College London, London, United Kingdom. Electronic address: maureen.taylor@imperial.ac.uk.
Imperial College London · GBEmory University · USStanford University · US

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
NIGMS NIH HHS P30 GM133894
6 · The paper itself

Abstract

The human mannose receptor expressed on macrophages and hepatic endothelial cells scavenges released lysosomal enzymes, glycopeptide fragments of collagen, and pathogenic microorganisms and thus reduces damage following tissue injury. The receptor binds mannose, fucose, or N-acetylglucosamine (GlcNAc) residues on these targets. C-type carbohydrate-recognition domain 4 (CRD4) of the receptor contains the site for Ca

Indexed as

Binding SitesCarbohydrate MetabolismCarbohydratesCrystallography, X-RayDisaccharidesGlycopeptidesGlycoproteinsHumansLectins, C-TypeLigandsMacrophagesMannoseMannose-Binding LectinsMannose ReceptorMembrane GlycoproteinsMonosaccharidesCarbohydratesDisaccharidesGlycopeptidesGlycoproteinsLectins, C-TypeLigandsMannoseMannose-Binding LectinsMannose ReceptorMembrane GlycoproteinsMonosaccharidesMRC1 protein, humanOligosaccharidesPolysaccharidesReceptors, Cell SurfaceReceptors, Immunologiccarbohydrate-binding proteinCD206crystal structureC-type lectinglycobiologyglycoproteinscavenger receptor

Identifiers

PMID33545173
PMCPMC7949135
OpenAlexW3128167142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.