Evidence map›Paper›PMID 33545121›Full record

ArticleExperimental eye research2021

Isolated human crystalline lens three-dimensional shape: A comparison between Indian and European populations.

Ashik Mohamed, Sushma Nandyala, Eduardo Martinez-Enriquez, Bianca Maceo Heilman, Robert C Augusteyn, Alberto de Castro, Marco Ruggeri, Jean-Marie A Parel, Susana Marcos, Fabrice Manns

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Ashik MohamedOphthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India; Brien Holden Vision Institute Limited, Sydney, Australia. Electronic address: ashikmohamed@lvpei.org.
Sushma NandyalaOphthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India.
Eduardo Martinez-EnriquezVisual Optics and Biophotonics Lab, Institute of Optics, Consejo Superior de Investigaciones Científicas (IO-CSIC), Madrid, Spain.
Bianca Maceo HeilmanOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL, USA.
Robert C AugusteynBrien Holden Vision Institute Limited, Sydney, Australia; Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Alberto de CastroVisual Optics and Biophotonics Lab, Institute of Optics, Consejo Superior de Investigaciones Científicas (IO-CSIC), Madrid, Spain.
Marco RuggeriOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL, USA.
Jean-Marie A ParelBrien Holden Vision Institute Limited, Sydney, Australia; Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL, USA; Anne Bates Leach Eye Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Susana MarcosVisual Optics and Biophotonics Lab, Institute of Optics, Consejo Superior de Investigaciones Científicas (IO-CSIC), Madrid, Spain.
Fabrice MannsOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL, USA.
University of Miami · USConsejo Superior de Investigaciones Científicas · ESL V Prasad Eye Institute · IN

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Optics of the Growing Crystalline LensR01EY021834 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MANNS, FABRICE · 2012 to 2016
$2.3M
NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY021834
6 · The paper itself

Abstract

There have been many studies on lens properties in specific populations (e.g. in China, Europe, Singapore, etc.) some of which suggest there may be differences between populations. Differences could be caused by ethnic or environmental influences or experimental procedures. The purpose of this study is to evaluate if any differences exist between Indian and European populations in the central geometric and full shape properties of human lenses. Two custom-developed spectral domain optical coherence tomography systems were used to acquire the crystalline lens geometry: one in India (69 lenses from 59 donors) and the other in Spain (24 lenses from 19 donors). The steps for obtaining accurate 3-D models from optical coherence tomography raw images comprised of image segmentation, fan and optical distortion correction, tilt removal and registration. The outcome variables were lens equatorial diameter, lens thickness, anterior and posterior lens thicknesses and their ratio, central radius of curvature of the anterior and posterior lens surfaces, lens volume and lens surface area. A mixed effects model by maximum likelihood estimation was used to evaluate the effect of age, population and their interaction (age*population) on lens parameters. After adjusting for age, there were no population differences observed in anterior and posterior radii of curvature, equatorial diameter, lens thickness, anterior and posterior lens thicknesses and their ratio, volume and surface area (all p ≥ 0.08). There was also no effect of the interaction term on anterior and posterior radii of curvature, equatorial diameter, lens thickness, anterior and posterior lens thicknesses and their ratio, volume and surface area (all p ≥ 0.06). All central geometric and full shape parameters appeared to be comparable between the European and Indian populations. This is the first study to compare geometric and full shape lens parameters between different populations in vitro.

Indexed as

AdultAsian PeopleBiometryHumansImage Processing, Computer-AssistedImaging, Three-DimensionalIndiaLens, CrystallineLikelihood FunctionsMiddle AgedModels, StatisticalOrganelle ShapeTomography, Optical CoherenceWhite PeopleYoung Adult3-D modelCrystalline lensGeometryHuman lensIn vitroOptical coherence tomographyPopulationShape

Identifiers

PMID33545121
PMCPMC8043973
OpenAlexW3127948672

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.