Evidence map›Paper›PMID 33545099›Full record

ArticleBrain research2021

GSNOR and ALDH2 alleviate traumatic spinal cord injury.

Mushfiquddin Khan, Fei Qiao, S M Touhidul Islam, Tajinder S Dhammu, Pavan Kumar, Jeseong Won, Avtar K Singh, Inderjit Singh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mushfiquddin KhanDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, United States. Electronic address: khanm@musc.edu.
Fei QiaoDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States. Electronic address: qiaof@musc.edu.
S M Touhidul IslamDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, United States. Electronic address: islamt@musc.edu.
Tajinder S DhammuDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, United States. Electronic address: dhammu@musc.edu.
Pavan KumarDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, United States. Electronic address: pavan.mathur@gmail.com.
Jeseong WonDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States. Electronic address: wonj@musc.edu.
Avtar K SinghDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States; Ralph H Johnson VA Medical Center, Charleston, SC, United States. Electronic address: singha@musc.edu.
Inderjit SinghDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, United States; Ralph H Johnson VA Medical Center, Charleston, SC, United States. Electronic address: singhi@musc.edu.
Medical University of South Carolina · USRalph H. Johnson VA Medical Center · US

Funding

EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR018823 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND, JOHN R · 2003 to 2003
$2.9M
MUSC FACIL EXPANSION &RENOV: SLE C06RR015455 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND, JOHN R · 2002 to 2002
$2.0M
Nitric Oxide Metabolism in Acute Traumatic Brain InjuryR21NS114433 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WON, JESEONG · 2020 to 2020
$414k
Mechanisms of Neuroprotective Therapy in TBII01BX003401 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI SINGH, AVTAR K · 2017 to 2020
–
Neurorestorative Therapy for Stroke InjuryI01RX002090 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI SINGH, INDERJIT · 2016 to 2020
–
BLRD VA I01 BX003401NCRR NIH HHS C06 RR015455NCRR NIH HHS C06 RR018823NINDS NIH HHS R21 NS114433RRD VA I01 RX002090
6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI) enhances the activity of S-nitrosoglutathione reductase (GSNOR) and inhibits the mitochondrial aldehyde dehydrogenase 2 (ALDH2) activity, resulting in prolonged and sustained pain and functional deficits. This study's objective was to test the hypotheses that GSNOR's specific inhibitor N6022 mitigates pain and improves functional recovery in a mouse model of SCI. Furthermore, the degree of recovery is enhanced and the rate of recovery is accelerated by an ALDH2 activator Alda-1. Using both wild-type and GSNOR

Indexed as

Alcohol DehydrogenaseAldehyde Dehydrogenase, MitochondrialAnimalsBenzamidesBenzodioxolesEnzyme InhibitorsMaleMiceMice, Inbred C57BLMice, KnockoutPyrrolesRecovery of FunctionSpinal Cord InjuriesAdh5 protein, mouseAlcohol DehydrogenaseAldehyde Dehydrogenase, MitochondrialALDH2 protein, mouseBenzamidesBenzodioxolesEnzyme InhibitorsN-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamideN6022PyrrolesAlda-1ALDH2BMS scoreGSNORN6022PainReactive aldehydesReactive oxygen speciesSCIS-nitrosylation

Identifiers

PMID33545099
PMCPMC7987823
OpenAlexW3126863678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.