ArticleCurrent biology : CB2021
A neuronal blueprint for directional mechanosensation in larval zebrafish.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Central complex representations of self-movement are sufficient to compute wind direction in flight.Science advances · 2026Article
- Critical period plasticity enables credit assignment.bioRxiv : the preprint server for biology · 2026Article
- Whole-body central processing of lateral line inputs encodes flow direction relative to the center-of-mass.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Optogenetic interrogation of the zebrafish lateral line reveals brain-wide neural circuits involved in pattern separation.iScience · 2025Article
- A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain.bioRxiv : the preprint server for biology · 2025Article
- Representation of bulk water flow in the goldfish (Carassius auratus) midbrain.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Article
- A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin.Neural development · 2024Article
- Sensing in the dark: Constructive evolution of the lateral line system in blind populations ofEcology and evolution · 2024Review
- Asymmetric mechanotransduction by hair cells of the zebrafish lateral line.Current biology : CB · 2023Article
- Physiological responses of mechanosensory systems in the head of larval zebrafish (Frontiers in robotics and AI · 2023Article
- Article
- Restoring Shank3 in the rostral brainstem of shank3ab-/- zebrafish autism models rescues sensory deficits.Communications biology · 2021Article
- Quantitative neuronal morphometry by supervised and unsupervised learning.STAR protocols · 2021Article
- Sensory adaptation at ribbon synapses in the zebrafish lateral line.The Journal of physiology · 2021Article
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Abstract
Animals have a remarkable ability to use local cues to orient in space in the absence of a panoramic fixed reference frame. Here we use the mechanosensory lateral line in larval zebrafish to understand rheotaxis, an innate oriented swimming evoked by water currents. We generated a comprehensive light-microscopy cell-resolution projectome of lateralis afferent neurons (LANs) and used clustering techniques for morphological classification. We find surprising structural constancy among LANs. Laser-mediated microlesions indicate that precise topographic mapping of lateral-line receptors is not essential for rheotaxis. Recording neuronal-activity during controlled mechanical stimulation of neuromasts reveals unequal representation of water-flow direction in the hindbrain. We explored potential circuit architectures constrained by anatomical and functional data to suggest a parsimonious model under which the integration of lateralized signals transmitted by direction-selective LANs underlies the encoding of water-flow direction in the brain. These data provide a new framework to understand how animals use local mechanical cues to orient in space.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.