ArticleCurrent biology : CB2021
Enhanced reinstatement of naturalistic event memories due to hippocampal-network-targeted stimulation.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Non-invasive Neuromodulation Targeting Approach by Mapping Stimulations and Lesions That Modify Visual Memory.bioRxiv : the preprint server for biology · 2026Article
- Neuronal signatures of successful one-shot memory in mid-level visual cortex.bioRxiv : the preprint server for biology · 2025Article
- From Correlation to Causation: Understanding Episodic Memory Networks.Neuroscience bulletin · 2025Review
- Neuromodulation of Fear and Anxiety Circuits.Current topics in behavioral neurosciences · 2025Review
- Causal and Chronological Relationships Predict Memory Organization for Nonlinear Narratives.Journal of cognitive neuroscience · 2024Article
- Brain functional specialization and cooperation in Alzheimer's disease.Brain and behavior · 2024Article
- Causally Probing the Role of the Hippocampus in Fear Discrimination: A Precision Functional Mapping-Guided, Transcranial Magnetic Stimulation Study in Participants With Posttraumatic Stress Symptoms.Biological psychiatry global open science · 2024Article
- Sense of own body shapes neural processes of memory encoding and reinstatement.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Neural similarity between overlapping events at learning differentially affects reinstatement across the cortex.NeuroImage · 2023Article
- Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods.Neuroscience and biobehavioral reviews · 2023Review
- Stimulation of distinct parietal locations differentiates frontal versus hippocampal network involvement in memory formation.Current research in neurobiology · 2022Article
- Imaging human engrams using 7 Tesla magnetic resonance imaging.Hippocampus · 2021Review
- Prefrontal stimulation prior to motor sequence learning alters multivoxel patterns in the striatum and the hippocampus.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Episodic memory involves the reinstatement of distributed patterns of brain activity present when events were initially experienced. The hippocampus is thought to coordinate reinstatement via its interactions with a network of brain regions, but this hypothesis has not been causally tested in humans. The current study directly tested the involvement of the hippocampal network in reinstatement using network-targeted noninvasive stimulation. We measured reinstatement of multi-voxel patterns of functional magnetic resonance imaging (fMRI) activity during encoding and retrieval of naturalistic video clips depicting everyday activities. Reinstatement of video-specific activity patterns was robust in posterior parietal and occipital areas previously implicated in event reinstatement. Theta-burst stimulation targeting the hippocampal network increased video-specific reinstatement of fMRI activity patterns in occipital cortex and improved memory accuracy relative to stimulation of a control out-of-network location. Furthermore, stimulation targeting the hippocampal network influenced the trial-by-trial relationship between hippocampal activity during encoding and later reinstatement in occipital cortex. These findings implicate the hippocampal network in the reinstatement of spatially distributed patterns of event-specific activity and identify a role for the hippocampus in encoding complex naturalistic events that later undergo cortical reinstatement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.