ArticleInternational wound journal2021
Significant presence of biofilm-producing gut-derived bacteria in anal fistula of chronic duration.
Article in International wound journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Autologous concentrated growth factors promote M2 macrophage polarization to accelerate wound healing after anal fistula surgery by activating the AKT/mTOR pathway.BMC gastroenterology · 2026Article
- Sphincter-preserving total fistulectomy: promising outcomes but questions remain.Updates in surgery · 2026Article
- Single-cell RNA sequencing reveals the therapeutic mechanism of Calvatia lilacina in promoting wound healing of anal fistula.Chinese medicine · 2026Article
- Risk factors for postoperative adverse outcomes in patients with high anal fistula undergoing modified TROPIS procedure combined with Parks' fistulotomy with seton: a retrospective study.Frontiers in medicine · 2026Article
- Associations between adjuvant antibiotic therapy and fistula formation after incision and drainage of anorectal abscesses: results from a retrospective cohort study.Techniques in coloproctology · 2025Article
- Ionic Liquid-Reinforced Multifunctional Hydrogel for the Treatment of Enterocutaneous Fistula.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- AMPEC4:Molecules (Basel, Switzerland) · 2025Article
- Catheter Injectable Multifunctional Biomaterial for the Treatment of Infected Enterocutaneous Fistulas.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- Microbial Succession on Microplastics in Wastewater Treatment Plants: Exploring the Complexities of Microplastic-Microbiome Interactions.Microbial ecology · 2024Review
- Microbiomic signatures of anal fistula and putative sources of microbes.Frontiers in cellular and infection microbiology · 2024Article
- Perioperative Factors Affecting the Healing of Rectovaginal Fistula.Journal of clinical medicine · 2023Review
- Treatments for the amelioration of persistent factors in complex anal fistula.Biotechnology letters · 2022Review
- Significant presence of biofilm-producing gut-derived bacteria in anal fistula of chronic duration.International wound journal · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fistula-in-ano though not a life-threatening condition, yet its symptoms often significantly impact patients' social, intimate, and work lives. There is an established role of bacterial microflora in acute infections. However, we proposed that biofilm-forming organisms might be present in the microflora of anal fistula of prolonged duration. This aspect has rarely been studied earlier. Therefore, the study describes the microbiology of anal fistula and the biofilm-forming capacity of the isolated organisms. A total of 30 patients were included in the study as per the criteria. Anal fistula tissue sample, tissue fluid, and blood samples were collected from each individual. The collected specimens were detected for the presence of aerobic and anaerobic microflora through standard microbiological method and polymerase chain reaction. Furthermore, the role of biofilm formation by microtitre plate assay and serum matrix metalloproteinases-9 was also studied. The result showed significant predominance of gut-derived microflora with high-to-moderate biofilm-producing ability in anal fistulas of prolonged duration. The study emphasises the presence of biofilm-forming bacteria in chronic, non-healing fistula.
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