ArticleHippocampus2021
Cross-regional phase amplitude coupling supports the encoding of episodic memories.
Article in Hippocampus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- TRanscranial AlterNating current stimulation FOR patients with mild Alzheimer's Disease (TRANSFORM-AD): a randomized controlled clinical trial.Alzheimer's research & therapy · 2024Trial
- Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.iScience · 2026Review
- Neurobiological mechanisms of 40-Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The genetic signature of memory encoding along the human hippocampal axis.bioRxiv : the preprint server for biology · 2026Article
- Flexible goal learning involves coordinated population activity in dCA1 and medial orbitofrontal cortex.PLoS biology · 2026Article
- Abnormal hippocampo-cortical theta-gamma phase-amplitude coupling in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- A functional MRI and magnetoencephalography study of the cognitive modulatory effect of transcranial direct current stimulation in early Alzheimer's disease.Frontiers in human neuroscience · 2026Article
- A pilot study of inter-regional phase amplitude coupling as comorbid depression biomarker in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2025Article
- Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory.Nature communications · 2025Article
- Models of human hippocampal specialization: a look at the electrophysiological evidence.Trends in cognitive sciences · 2025Review
- Type-2 Diabetes Alters Hippocampal Neural Oscillations and Disrupts Synchrony between the Hippocampus and Cortex.Aging and disease · 2024Article
- Article
- Theta-Alpha Connectivity in the Hippocampal-Entorhinal Circuit Predicts Working Memory Load.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neurophysiological mechanisms of cognition in the developing brain: Insights from intracranial EEG studies.Developmental cognitive neuroscience · 2023Review
- Machine learning classifiers for electrode selection in the design of closed-loop neuromodulation devices for episodic memory improvement.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Episodic boundary cells in human medial temporal lobe during the free recall task.Hippocampus · 2022Article
- Theta low-gamma phase amplitude coupling in the human orbitofrontal cortex increases during a conflict-processing task.Journal of neural engineering · 2022Article
- Anterior-Posterior Hippocampal Dynamics Support Working Memory Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Epileptogenic Zone Location of Temporal Lobe Epilepsy by Cross-Frequency Coupling Analysis.Frontiers in neurology · 2021Article
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5 authors.
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Abstract
Phase amplitude coupling (PAC) between theta and gamma oscillations represents a key neurophysiological mechanism that promotes the temporal organization of oscillatory activity. For this reason, PAC has been implicated in item/context integration for episodic processes, including coordinating activity across multiple cortical regions. While data in humans has focused principally on PAC within a single brain region, data in rodents has revealed evidence that the phase of the hippocampal theta oscillation modulates gamma oscillations in the cortex (and vice versa). This pattern, termed cross-regional PAC (xPAC), has not previously been observed in human subjects engaged in mnemonic processing. We use a unique dataset with intracranial electrodes inserted simultaneously into the hippocampus and seven cortical regions across 40 human subjects to (1) test for the presence of significant cross-regional PAC (xPAC), (2) to establish that the magnitude of xPAC predicts memory encoding success, (3) to describe specific frequencies within the broad 2-9 Hz theta range that govern hippocampal-cortical interactions in xPAC, and (4) compare anterior versus posterior hippocampal xPAC patterns. We find that strong functional xPAC occurs principally between the hippocampus and other mesial temporal structures, namely entorhinal and parahippocampal cortices, and that xPAC is overall stronger for posterior hippocampal connections. We also show that our results are not confounded by alternative factors such as inter-regional phase synchrony, local PAC occurring within cortical regions, or artifactual theta oscillatory waveforms.
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