Evidence map›Paper›PMID 33544370›Full record

Trial reportCerebellum (London, England)2021

Cerebellar rTMS in PSP: a Double-Blind Sham-Controlled Study Using Mobile Health Technology.

Andrea Pilotto, Maria Cristina Rizzetti, Alberto Lombardi, Clint Hansen, Michele Biggi, Giacomo Verzeroli, Antonella Martinelli, Robbin Romijnders, Barbara Borroni, Walter Maetzler and 1 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cerebellum (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Theta-burst stimulation as a therapeutic tool in neurological pathology: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  2. Pooled it
  3. Review
  4. Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Andrea PilottoNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.zale Spedali Civili, 1, 25123, Brescia, Italy. pilottoandreae@gmail.com.ORCID http://orcid.org/0000-0003-2029-6606
Maria Cristina RizzettiParkinson's Disease Rehabilitation Unit, FERB Onlus Trescore Balneario, Bergamo, Italy.
Alberto LombardiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.zale Spedali Civili, 1, 25123, Brescia, Italy.
Clint HansenDepartment of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Michele BiggiPhysical Therapy Unit, Milano Bicocca University, Bergamo, Italy.
Giacomo VerzeroliPhysical Therapy Unit, Milano Bicocca University, Bergamo, Italy.
Antonella MartinelliPhysical Therapy Unit, Milano Bicocca University, Bergamo, Italy.
Robbin RomijndersDepartment of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Barbara BorroniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.zale Spedali Civili, 1, 25123, Brescia, Italy.
Walter MaetzlerDepartment of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P.zale Spedali Civili, 1, 25123, Brescia, Italy.
Christian-Albrechts-Universität zu Kiel · DEUniversity of Brescia · ITUniversity of Milano-Bicocca · ITFondazione Europea Ricerca Biomedica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are no effective treatments in progressive supranuclear palsy (PSP). The aim of this study was to test the efficacy of theta burst repetitive transcranial magnetic stimulation (rTMS) on postural instability in PSP. Twenty PSP patients underwent a session of sham or real cerebellar rTMS in a crossover design. Before and after stimulation, static balance was evaluated with instrumented (lower back accelerometer, Rehagait®, Hasomed, Germany) 30-s trials in semitandem and tandem positions. In tandem and semitandem tasks, active stimulation was associated with increase in time without falls (both p=0.04). In the same tasks, device-extracted parameters revealed significant improvement in area (p=0.007), velocity (p=0.005), acceleration and jerkiness of sway (p=0.008) in real versus sham stimulation. Cerebellar rTMS showed a significant effect on stability in PSP patients, when assessed with mobile digital technology, in a double-blind design. These results should motivate larger and longer trials using non-invasive brain stimulation for PSP patients.

Indexed as

Supranuclear Palsy, ProgressiveTranscranial Magnetic StimulationBiomedical TechnologyCerebellumDouble-Blind MethodHumansTreatment OutcomeMobile health technologyPostural instabilityProgressive supranuclear palsyRepetitive transcranial magnetic stimulation

Identifiers

PMID33544370
PMCPMC8360898
OpenAlexW3127937866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.