Evidence map›Paper›PMID 33544319›Full record

ReviewCurrent hematologic malignancy reports2021

Joining Efforts for PTLD: Lessons Learned from Comparing the Approach and Treatment Strategies Across the Pediatric and Adult Age Spectra.

Francesca Montanari, Manuela Orjuela-Grimm

Open access · greenAbstract readReview
In one paragraph

Review in Current hematologic malignancy reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. EBV Reactivation and Lymphomagenesis: More Questions than Answers.Current hematologic malignancy reports · 2023
    Review
  6. Review
  7. Non-Hodgkin lymphoma after pediatric kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Francesca MontanariDepartment of Hematology, Yale Cancer Center, Smilow Cancer Hospital, New Haven, USA.
Manuela Orjuela-GrimmDivision of Pediatric Hematology, Oncology, and Stem Cell Transplant, Departments of Pediatrics and Epidemiology, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, Mailman School of Public Health, 722 West 168th street, Room 730, New York, NY, 10032, USA. Mao5@cumc.columbia.edu.
Columbia University Irving Medical Center · USSmilow Cancer Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Methylation and mutations in RB1 and variants of synthetic folic acid metabolismR01CA192662 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ORJUELA, MANUELA A · 2015 to 2018
$1.5M
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA192662
6 · The paper itself

Abstract

purpose of reviewPost-transplant lymphoproliferative disorders are a rare and heterogeneous group of diseases, where large prospective studies have been difficult to perform and treatment paradigms are often based on retrospective studies. Here, we critically analyze and present the clinical algorithms commonly used for this disease, with a special focus on the challenges and differences of the approaches in the adult and pediatric populations. RECENT

findingsClinical trials exploring combinations of immunochemotherapies with a sequential and risk-stratified strategy have demonstrated exciting results, but are hampered from specialty and age-determined silos. Approaches introducing novel-targeted therapies and cellular therapies are currently being explored with a goal of joining efforts across the pediatric and adult age spectra. We propose that future therapeutic approaches would benefit from combining pediatric and adult PTLD efforts, gaining from the experience garnered from the age- and subtype-specific tailored strategies, with the aim of limiting treatment-related toxicities while maximizing the efficacy. Joining of efforts holds enormous potential for accelerating access to novel therapeutic strategies for PTLD in the near future.

Indexed as

AdultAntineoplastic Agents, ImmunologicalBone Marrow TransplantationChildHumansImmunotherapyImmunotherapy, AdoptiveLymphoproliferative DisordersRituximabStem Cell TransplantationAntineoplastic Agents, ImmunologicalRituximabAdoptive T cell therapyAdultsBrentuximab vedotinImmunochemotherapyImmunosuppression reductionPediatricsPost-transplant lymphoproliferative disorders (PTLD)Rituximab

Identifiers

PMID33544319
PMCPMC8117403
OpenAlexW3127180963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.