ArticleThe international journal of cardiovascular imaging2021
Incremental prognostic role of left atrial reservoir strain in asymptomatic patients with moderate aortic stenosis.
Article in The international journal of cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Effect of immune checkpoint inhibitor therapy on biventricular mechanics in cancer patients over a short-term follow-up: a systematic review.Frontiers in immunology · 2025Pooled it
- Prognostic value of left atrial strain in significant aortic valve disease: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Left and Right Atrial Strain Across the Heart Failure Continuum: Multifaceted Markers of Subclinical Mechanical Dysfunction and Haemodynamic Burden.Diagnostics (Basel, Switzerland) · 2026Review
- Myocardial Deformation Analysis in Congenital Aortic Valve Stenosis: Comparison Across Clinical Phenotypes in Children.Pediatric cardiology · 2026Article
- Association of Subclinical Cardiac Remodeling With Incident Cancer in the MESA Cohort.Journal of the American Heart Association · 2026Article
- Prognostic Role of Left Atrial Reservoir Strain for Risk Stratification in Aortic Stenosis: A Systematic Review.Journal of clinical medicine · 2026Review
- Effect of Immune Checkpoint Inhibitor Therapy on Biventricular and Biatrial Mechanics in Patients with Advanced Cancer: A Short-Term Follow-Up Study.Journal of clinical medicine · 2026Article
- Temporal Cardiorenal Dynamics and Mortality Prediction After TAVR: The Prognostic Value of the 48-72 h BUN/EF Ratio.Journal of clinical medicine · 2026Article
- Left Atrial Reservoir Strain in Cardiovascular and Systemic Disease: Advances and Clinical Applications From Physiology to Practice.Reviews in cardiovascular medicine · 2025Review
- Atrial Cardiomyopathy: A "Distinct Clinical Entity" for a Deeper Understanding of Atrial Fibrillation and Cardioembolic Stroke.Journal of clinical medicine · 2025Review
- Exercise Stress Echocardiography Predicts Adverse Cardiovascular Events in Hypertrophic Cardiomyopathy: A 5-Year Prospective Study.Reviews in cardiovascular medicine · 2025Article
- Impact of Aortic Stenosis Severity on Left Heart Function Analyzed Using CT-Derived Strain Parameters.Korean journal of radiology · 2025Article
- Left Atrial Strain-Current Review of Clinical Applications.Diagnostics (Basel, Switzerland) · 2025Review
- Long-Term Prognostic Power of Three-Dimensional Speckle-Tracking Echocardiography-Derived Peak Left Atrial Reservoir Global Longitudinal Strain in Healthy Adults-An Analysis from the MAGYAR-Healthy Study.Life (Basel, Switzerland) · 2025Article
- The Clinical Applications of Left Atrial Strain: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2024Review
- Echocardiographic Parameters and Complication Profiles Among Adult Patients with Rheumatic Heart Disease at Jimma Medical Center.Vascular health and risk management · 2024Article
- Atrial Cardiomyopathy in Valvular Heart Disease: From Molecular Biology to Clinical Perspectives.Cells · 2023Review
- Assessment the Predictive Value of Left Atrial Strain (LAS) on Exercise Tolerance in HCM Patients with E/e' between 8 and 14 by Two-Dimensional Speckle Tracking and Treadmill Stress Echocardiography.Reviews in cardiovascular medicine · 2023Article
- Prognostic role of CHAInternal and emergency medicine · 2023Article
- In-Hospital Outcomes of Heart Failure Patients with Valvular Heart Disease: Insights from Real-World Claims Data.ClinicoEconomics and outcomes research : CEOR · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Left atrial (LA) mechanics assessed by two-dimensional speckle tracking echocardiography (2D-STE) have not been extensively studied and clearly characterized in patients with moderate aortic stenosis (AS). Accordingly, we aimed to evaluate the usefulness of LA reservoir strain for risk stratification of asymptomatic patients with moderate AS. This retrospective study included all consecutive asymptomatic patients with moderate AS who underwent transthoracic echocardiography implemented with 2D-STE analysis of LA myocardial strain and strain rate indices at our Institution, between February 2011 and September 2019. During the follow-up period, we evaluated the occurrence of any of the following: (1) CV hospitalization; (2) The recourse to AS surgery; (3) Cardiac death or sudden death. A total of 186 patients (mean age 71.9 ± 12.7 years, 61.8% men) were included in the present study. During a mean follow-up of 2.3 ± 1.9 years, no patients died and 63 adverse CV events were recorded: 48 patients were hospitalized because of heart failure (28 patients), acute coronary syndrome (10 patients), arrhythmias (10 patients) and 15 patients underwent AS surgery. At the multivariate Cox regression analysis, type 2 diabetes mellitus (OR 1.87, 95%CI 1.05-3.34, p = 0.03), NT-proBNP (OR average 1.14, 95%CI 1.02-1.27, p = 0.02), average E/e' ratio (OR 1.07, 95%CI 1.01-1.15, p = 0.04) and most of all left atrial positive global strain (LA-GSA+) (OR 0.85, 95%CI 0.81-0.90, p < 0.0001) were independently associated with the outcome. LA-GSA+ (optimal cut-off ≤ 19%, AUC = 0.94, 87% sensitivity, 99% specificity, positive predictive value 99%, negative predictive value 88%) showed the highest diagnostic performance. An impaired LA reservoir strain can contribute to identify a subset of asymptomatic patients with moderate AS at higher risk, who may benefit from closer echocardiographic follow-up and/or early surgery.
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