ReviewWorld journal of microbiology & biotechnology2021
SigB-regulated antioxidant functions in gram-positive bacteria.
Review in World journal of microbiology & biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Land-Use and Depth-Dependent Assembly of Soil Microbiomes Shapes Ecological Functions, Interaction Networks, and Phytopathogenic Communities Across Crop and Orchard Systems.Antioxidants (Basel, Switzerland) · 2026Article
- Staphylococcus aureus's golden-yellow pigment staphyloxanthin: production enhancement, analytical characterization, and biological attributes.Microbial cell factories · 2026Review
- Advances in stress-tolerance elements for microbial cell factories.Synthetic and systems biotechnology · 2024Review
- GlmS plays a key role in the virulence factor expression and biofilm formation ability ofVirulence · 2024Article
- Genomic Functional Analysis of Novel Radiation-Resistant Species ofMicroorganisms · 2024Article
- CodY: An Essential Transcriptional Regulator Involved in Environmental Stress Tolerance in FoodborneFoods (Basel, Switzerland) · 2023Article
- Implication of the σMicrobiology spectrum · 2023Article
- Influence of dietary vitamin E and selenium supplementation on broilers subjected to heat stress, Part II: oxidative stress, immune response, gut integrity, and intestinal microbiota.Poultry science · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress can have lethal consequences if organisms do not respond and remediate the damage to DNA, proteins and lipids. Bacterial species respond to oxidative stress by activating transcriptional profiles that include biochemical functions to reduce oxidized cellular components, regenerate pools of reducing molecules, and detoxify harmful metabolites. Interestingly, the general stress response in Gram positive bacteria controlled by SigB is induced by oxidative stress from reactive oxygen and electrophilic species. The upregulation of SigB regulated genes during exposure to electrophilic and oxidative compounds suggests SigB contributes directly to the adaptations required for oxidative stress survival. A subset of the functions of SigB regulated genes can be categorized with antioxidant biochemical activities, such as redoxins, reductases and dehydrogenases, including regulation of low molecular weight thiols, yet their exact cellular role is not fully understood. Here, we present an overview of the predicted antioxidant biochemical functions regulated by SigB, with potential for biomedical research given the prevalence of oxidative stress during bacterial infection, as well as during industrial applications of large-scale production of compounds by microbes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.