Evidence map›Paper›PMID 33544223›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2021

A novel classification and its clinical significance in Chiari I malformation with syringomyelia based on high-resolution MRI.

Jian Guan, Chenghua Yuan, Can Zhang, Longbing Ma, Qingyu Yao, Lei Cheng, Zhenlei Liu, Kai Wang, Wanru Duan, Xingwen Wang and 4 more

Erratum issued Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04856839 (Phenotypes, Biomarkers and Pathophysiology in Syringomyelia), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04856839 unknown statusnot on this map

Phenotypes, Biomarkers and Pathophysiology in Syringomyelia

TypeobservationalSponsorXuanwu Hospital, BeijingRan2021 to 2025Enrolled200ConditionsSyringomyelia/HydromyeliaArmshigh throughput sequencing and electromyography
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Natural history of Chiari I malformation-syringomyelia: longitudinal cohort study.Journal of neurology, neurosurgery, and psychiatry · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jian Guan *Department of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Chenghua Yuan *Department of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Can ZhangDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Longbing MaDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Qingyu YaoDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Lei ChengDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Zhenlei LiuDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Kai WangDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Wanru DuanDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Xingwen WangDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Zuowei WangDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Hao WuDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China.
Zan ChenDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China. chenzan66@163.com.
Fengzeng JianDepartment of Neurosurgery, Division of Spine, China, International Neurological Institute, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, People's Republic of China. jianfengzeng@xwh.ccmu.edu.cn.ORCID 0000-0001-7860-278X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe existing classification in Chiari I malformation (CM-I) has limited significance for the selection of surgical methods.

objectiveThe purpose of this study was to investigate the surgery of CM-I with syringomyelia based on the high-resolution MR imaging (HRMRI) findings.

methodsData from 115 patients were collected and retrospectively analyzed. For those with syringomyelia up to the level of C1, HRMRI was performed and according to the communication status between the fourth ventricle and the syringomyelia, patients can be divided into four types, namely Type A: classic communicating; Type B: partial communicating; Type C: non-communicating; Type D: atrophic. All operations were performed with Foramen magnum and Magendie dredging (FMMD), and all intradural factors that may have induced the obstruction of CSF circulation were recorded. The efficiency of operation on syringomyelia was evaluated by mJOA, imaging findings, and complications in the follow-up periods.

resultsThe postoperative follow-up period was from 12 to 24 months, with an average of 14.3 months. At 1 year, the mJOA of 115 patients was significantly higher than that before the operations (before surgery 12.1 ± 2.3 vs. after surgery 14. 2 ± 1.4, P < 0.05). In addition, postoperative re-examination showed that the size of the syringomyelia was reduced or completely resolved in patients of Type A, 100% (2/2); Type B, 81% (9/11); Type C, 84% (81/97); and Type D, 20% (1/5).

conclusionsAccording to our new classification based on HRMRI, FMMD is the key to surgical treatment, especially for Type A and Type B patients.

Indexed as

Arnold-Chiari MalformationSyringomyeliaForamen MagnumHumansMagnetic Resonance ImagingRetrospective StudiesTreatment OutcomeCerebrospinal fluidChiari malformation Type IHigh-resolution MRISyringomyeliaType

Identifiers

PMID33544223

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Registered trials

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