ArticleJournal of neurology2021
Effects of Levodopa on quality of sleep and nocturnal movements in Parkinson's Disease.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of Exercise-Based Interventions on Self-Reported Sleep Outcomes in Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Bioengineering (Basel, Switzerland) · 2026Review
- Spatio-temporal gait signatures across prodromal and early Parkinson's disease in two independent cohorts.Scientific reports · 2026Article
- The Effect of Deep Brain Stimulation on Sleep and Cognition in Patients With Parkinson's Disease.Journal of sleep research · 2026Article
- Patterns of weariness-related symptoms in Parkinson's disease: impact of disease progression and levodopa treatment.Clinical parkinsonism & related disorders · 2026Article
- The Effect of Dopaminergic Therapies in Parkinson's Disease on Non-Motor Symptoms.International journal of molecular sciences · 2025Review
- Update on sleep disorders in advanced Parkinson's disease: a narrative review.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Butyrate improves abnormal sleep architecture in a Parkinson's disease mouse model via BDNF/TrkB signaling.NPJ Parkinson's disease · 2025Article
- Modernizing the Staging of Parkinson Disease Using Digital Health Technology.Journal of medical Internet research · 2025Article
- Effects of dopaminergic therapy on sleep quality in fluctuating Parkinson's disease patients.Journal of neurology · 2024Article
- Short-Term Therapeutic Effect of Repetitive Transcranial Magnetic Stimulations of Sleep Disorders in Parkinson's Disease: A Randomized Clinical Trial (Pilot Study).Brain sciences · 2024Article
- Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder.IEEE open journal of engineering in medicine and biology · 2024Article
- Effect ofFrontiers in pharmacology · 2024Article
- Controlled-Release Levodopa for the Treatment of Rapid Motor Fluctuations in Parkinson's Disease Subjects with Subthalamic Nucleus Deep Brain Stimulation.Asian journal of neurosurgery · 2023Article
- Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons.Experimental and therapeutic medicine · 2022Article
- Management of Sleep Disturbances in Parkinson's Disease.Journal of Parkinson's disease · 2022Review
- Low-Dose Niacin Supplementation Improves Motor Function in US Veterans with Parkinson's Disease: A Single-Center, Randomized, Placebo-Controlled Trial.Biomedicines · 2021Article
- A randomised controlled trial on effectiveness and feasibility of sport climbing in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Sleep Disturbances and Associated Factors in Drug-Naïve Patients with Parkinson's Disease.Neuropsychiatric disease and treatment · 2021Article
- Levodopa-accelerated frailty: a hypothesis for a cumulative iatrogenic burden in Parkinson's disease.Frontiers in neurologyArticle
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSleep disturbances are common in Parkinson's Disease (PD), with nocturnal akinesia being one of the most burdensome. Levodopa is frequently used in clinical routine to improve nocturnal akinesia, although evidence is not well proven.
methodsWe assessed associations of Levodopa intake with quality of sleep and perception of nocturnal akinesia in three PD cohorts, using the Parkinson's Disease Sleep Scale (PDSS-2) in two cohorts and a question on nocturnal immobility in one cohort. In one cohort also objective assessment of mobility during sleep was performed, using mobile health technology.
resultsIn an independent analysis of all three cohorts (in total n = 1124 PD patients), patients taking Levodopa CR reported a significantly higher burden by nocturnal akinesia than patients without Levodopa. Higher Levodopa intake and MDS-UPDRS part IV scores (indicating motor fluctuations) predicted worse PDSS-2 and higher subjective nocturnal immobility scores, while disease duration and severity were not predictive. Levodopa intake was not associated with objectively changed mobility during sleep.
conclusionOur results showed an association of higher Levodopa intake with perception of worse quality of sleep and nocturnal immobility in PD, indicating that Levodopa alone might not be suitable to improve subjective feeling of nocturnal akinesia in PD. In contrast, Levodopa intake was not relevantly associated with objectively measured mobility during sleep. PD patients with motor fluctuations may be particularly affected by subjective perception of nocturnal mobility. This study should motivate further pathophysiological and clinical investigations on the cause of perception of immobility during sleep in PD.
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