Evidence map›Paper›PMID 33544169›Full record

ArticleDiabetologia2021

Size for gestational age affects the risk for type 1 diabetes in children and adolescents: a Swedish national case-control study.

Nina Lindell, Marie Bladh, Annelie Carlsson, Ann Josefsson, Karin Aakesson, Ulf Samuelsson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nina LindellDepartment of Obstetrics and Gynecology, Linköping University, Linköping, Sweden. nina.lindell@liu.se.ORCID https://orcid.org/0000-0001-7562-3040
Marie BladhDepartment of Obstetrics and Gynecology, Linköping University, Linköping, Sweden.ORCID https://orcid.org/0000-0002-6681-8601
Annelie CarlssonDepartment of Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-5608-3437
Ann JosefssonDepartment of Obstetrics and Gynecology, Linköping University, Linköping, Sweden.ORCID https://orcid.org/0000-0003-3238-3811
Karin AakessonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID https://orcid.org/0000-0003-2556-5094
Ulf SamuelssonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID https://orcid.org/0000-0002-2837-4237
Linköping University · SELund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim/hypothesisEnvironmental factors are believed to contribute to the risk of developing type 1 diabetes. The aim of this study was to investigate how size for gestational age affects the risk of developing childhood type 1 diabetes.

methodsUsing the Swedish paediatric diabetes quality register and the Swedish medical birth register, children with type 1 diabetes diagnosed between 2000 and 2012 (n = 9376) were matched with four control children (n = 37,504). Small for gestational age (SGA) and large for gestational age (LGA) were defined according to Swedish national standards. Data were initially analysed using Pearson's χ

resultsAn equal proportion of children were born appropriate for gestational age, but children with type 1 diabetes were more often born LGA and less often born SGA than control children (4.7% vs 3.5% and 2.0% vs 2.6%, respectively, p < 0.001). In the multiple logistic regression analysis, being born LGA increased (adjusted OR 1.16 [95% CI 1.02, 1.32]) and SGA decreased (adjusted OR 0.76 [95% CI 0.63, 0.92]) the risk for type 1 diabetes, regardless of maternal BMI and diabetes. CONCLUSIONS/

interpretationSize for gestational age of Swedish children affects the risk of type 1 diabetes, with increased risk if the child is born LGA and decreased risk if the child is born SGA. Being born LGA is an independent risk factor for type 1 diabetes irrespective of maternal BMI and diabetes. Thus, reducing the risk for a child being born LGA might to some extent reduce the risk for type 1 diabetes.

Indexed as

Gestational AgeAdolescentAge of OnsetBirth WeightCase-Control StudiesChildChild, PreschoolDiabetes Mellitus, Type 1FemaleFetal DevelopmentFetal MacrosomiaFetusHumansInfant, NewbornInfant, Small for Gestational AgeMaleAge at onsetChildrenEpidemiologyLarge for gestational ageRisk factorSmall for gestational ageType 1 diabetes

Identifiers

PMID33544169
PMCPMC8012313
OpenAlexW3128601393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.