ReviewChemical reviews2021
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.
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Review in Chemical reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 240 papers.
0numbers the graph read from it
0cells of the map it votes in
240citing papers in PubMed
62.2field-weighted citation impact, top 1% of its field
What it found
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Who cites it
240 citing papers in PubMed, 645 citations in OpenAlex.
- Targeting soluble misfolded oligomers in anti-amyloid research.Nature reviews. Chemistry · 2026Review
- Neuroinflammation in Alzheimer's and Parkinson's diseases: pathogenic mechanisms and therapeutic strategies.Translational neurodegeneration · 2026Review
- Molecular Dynamics Simulations of AβACS omega · 2026Article
- Disentangling Intrachain Folding from Interchain Assembly through Multidimensional Visualization.The journal of physical chemistry. B · 2026Article
- A Prodrug Approach for Activity-Based Chemical Modulation toward Multiple Pathological Targets in Alzheimer's Disease.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- HyRes: Accurate Physics-Based Simulation of Dynamic Protein Structures and Interactions in Complex Environments at Scale.bioRxiv : the preprint server for biology · 2026Article
- The Monomeric Conformational Ensembles of Aβ40 and Aβ42 Encode Their Differential Amyloid Aggregation Propensity.The journal of physical chemistry. B · 2026Article
- An edge β-strand mutation turns ubiquitin into a pore-forming amyloid.Protein science : a publication of the Protein Society · 2026Article
- RBM45 Preferential Binding to mThe journal of physical chemistry. B · 2026Article
- α,β-Dehydroamino-Acid-Containing Peptides Resist Proteolysis and Inhibit Aggregation of a Tau-Derived Model Peptide.The Journal of organic chemistry · 2026Article
- Fluorescent non-canonical amino acid as a site-specific conformational probe of prion formation.bioRxiv : the preprint server for biology · 2026Article
- Identification of Secondary Nucleation Inhibitors of Amyloid-β Aggregation by Cellular Selection of a SICLOPPS Library.Chembiochem : a European journal of chemical biology · 2026Article
- Lipid Composition Drastically Alters Tau-Membrane Interaction: Implications for Alzheimer's Disease.JACS Au · 2026Article
- Toxic mechanisms of amyloid oligomers and therapeutic strategies.Protein science : a publication of the Protein Society · 2026Review
- Stability and Dynamics of the N‑Terminal Domain of TDP-43 and the Effect of Point Mutations.ACS omega · 2026Article
- Self-assembled metabolite-derived amyloid-like structures: implications for disease, therapeutics, and biomedical applications.Molecular biology reports · 2026Review
- Clinically relevant stereochemistry reprograms amyloid proteome for aggregation cross-talk-conferred neuroprotection.Science advances · 2026Article
- Higher Magnetic Field NMR Renders Resolution Enhancement on Ganglioside GD3 Catalyzed AβbioRxiv : the preprint server for biology · 2026Article
- Structural and mechanistic characterization of heparin interactions with tau fibrils.The Journal of biological chemistry · 2026Article
- Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers.Neurobiology of disease · 2026Article
180 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 19 institutions in 10 countries.
Phuong H NguyenCNRS, UPR9080, Université de Paris, Laboratory of Theoretical Biochemistry, IBPC, Fondation Edmond de Rothschild, PSL Research University, Paris 75005, France.ORCID 0000-0003-1284-967X
Ayyalusamy RamamoorthyBiophysics and Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, United States.ORCID 0000-0003-1964-1900
Bikash R SahooBiophysics and Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, United States.ORCID 0000-0002-3683-1178
Jie ZhengDepartment of Chemical & Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, United States.ORCID 0000-0003-1547-3612
Peter FallerInstitut de Chimie, UMR 7177, CNRS-Université de Strasbourg, 4 rue Blaise Pascal, 67000 Strasbourg, France.ORCID 0000-0001-8013-0806
John E StraubDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.ORCID 0000-0002-2355-3316
Laura DominguezFacultad de Química, Departamento de Fisicoquímica, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.ORCID 0000-0003-3666-2789
Joan-Emma SheaDepartment of Chemistry and Biochemistry, and Department of Physics, University of California, Santa Barbara, California 93106, United States.ORCID 0000-0002-9801-9273
Nikolay V DokholyanDepartment of Pharmacology and Biochemistry & Molecular Biology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, United States.ORCID 0000-0002-8225-4025
Alfonso De SimoneDepartment of Life Sciences, Imperial College London, London SW7 2AZ, U.K.
Buyong MaBasic Science Program, Leidos Biomedical Research, Inc., Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland 21702, United States.ORCID 0000-0002-7383-719X
Ruth NussinovBasic Science Program, Leidos Biomedical Research, Inc., Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland 21702, United States.
Saeed NajafiDepartment of Chemistry and Biochemistry, and Department of Physics, University of California, Santa Barbara, California 93106, United States.
Son Tung NgoLaboratory of Theoretical and Computational Biophysics & Faculty of Applied Sciences, Ton Duc Thang University, 33000 Ho Chi Minh City, Vietnam.ORCID 0000-0003-1034-1768
Antoine LoquetInstitute of Chemistry & Biology of Membranes & Nanoobjects, (UMR5248 CBMN), CNRS, Université Bordeaux, Institut Européen de Chimie et Biologie, 33600 Pessac, France.ORCID 0000-0001-7176-7813
Mara ChiricottoDepartment of Chemical Engineering and Analytical Science, University of Manchester, Manchester M13 9PL, U.K.
Pritam GangulyDepartment of Chemistry and Biochemistry, and Department of Physics, University of California, Santa Barbara, California 93106, United States.ORCID 0000-0002-6299-3111
James McCartyChemistry Department, Western Washington University, Bellingham, Washington 98225, United States.ORCID 0000-0002-3838-6004
Mai Suan LiInstitute for Computational Science and Technology, SBI Building, Quang Trung Software City, Tan Chanh Hiep Ward, District 12, Ho Chi Minh City 700000, Vietnam.ORCID 0000-0001-7021-7916
Carol HallDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695-7905, United States.ORCID 0000-0002-7425-587X
Yiming WangDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695-7905, United States.ORCID 0000-0003-3657-6100
Yifat MillerDepartment of Chemistry and The Ilse Katz Institute for Nanoscale Science & Technology, Ben-Gurion University of the Negev, Be'er Sheva 84105, Israel.ORCID 0000-0002-1163-9745
Simone MelchionnaISC-CNR, via dei Taurini, 00185 Rome, Italy.
Birgit HabensteinInstitute of Chemistry & Biology of Membranes & Nanoobjects, (UMR5248 CBMN), CNRS, Université Bordeaux, Institut Européen de Chimie et Biologie, 33600 Pessac, France.
Stepan TimrCNRS, UPR9080, Université de Paris, Laboratory of Theoretical Biochemistry, IBPC, Fondation Edmond de Rothschild, PSL Research University, Paris 75005, France.
Jiaxing ChenDepartment of Pharmacology and Biochemistry & Molecular Biology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, United States.
Brianna HnathDepartment of Pharmacology and Biochemistry & Molecular Biology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, United States.
Birgit StrodelInstitute of Complex Systems: Structural Biochemistry (ICS-6), Forschungszentrum Jülich, 52425 Jülich, Germany.ORCID 0000-0002-8734-7765
Rakez KayedMitchell Center for Neurodegenerative Diseases, and Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555, United States.ORCID 0000-0001-6216-8640
Sylvain LesnéDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Guanghong WeiDepartment of Physics, State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Science, Multiscale Research Institute of Complex Systems, Fudan University, Shanghai 200438, China.ORCID 0000-0001-5814-3328
Fabio SterponeCNRS, UPR9080, Université de Paris, Laboratory of Theoretical Biochemistry, IBPC, Fondation Edmond de Rothschild, PSL Research University, Paris 75005, France.ORCID 0000-0003-0894-8069
Andrew J DoigDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, U.K.ORCID 0000-0003-0346-2270
Philippe DerreumauxCNRS, UPR9080, Université de Paris, Laboratory of Theoretical Biochemistry, IBPC, Fondation Edmond de Rothschild, PSL Research University, Paris 75005, France.ORCID 0000-0001-9110-5585
Centre National de la Recherche Scientifique · FRPennsylvania State University · USUniversity of California, Santa Barbara · USLeidos (United States) · USNorth Carolina State University · USUniversity of Manchester · GBUniversity of Michigan · USBen-Gurion University of the Negev · ILBoston University · USForschungszentrum Jülich · DEFudan University · CNImperial College London · GBInstitute for Computational Science and Technology · VNThe University of Texas Medical Branch at Galveston · USTon Duc Thang University · VNUniversidad Nacional Autónoma de México · MXUniversity of Akron · USUniversity of Minnesota · USWestern Washington University · US
Funding
Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7MProtein Structure, Stability, and Amyloid FormationZIABC010440 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSINOV, RUTH · 2009 to 2025
$11.8MBiomolecular Recognition and Binding MechanismsZIABC010441 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSINOV, RUTH · 2009 to 2025
$9.4MFormation and Propagation of Tau Oligomeric Strains in Alzheimer's DiseaseR01AG054025 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Rakez Kayed · 2016 to 2026
$5.8MNanoscale programming of cellular and physiological phenotypes: EquipmentR35GM134864 · NIGMS · UNIVERSITY OF VIRGINIA · PI Nikolay Dokholyan · 2020 to 2026
$5.2MAMP-Kinase as a target for neuroprotection in ADRF1AG062135 · NIA · UNIVERSITY OF MINNESOTA · PI LEE, MICHAEL K, TRUSHINA, EUGENIA · 2019 to 2019
$3.2MIntersection of alpha synuclein and tau contributions to neurotoxicityR01NS094557 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI DINELEY, KELLY T, KAYED, RAKEZ · 2016 to 2020
$2.8MProbing the roles of membrane and cholesterol on Aβ biogenesis and prion protein interactionsR01GM107703 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI STRAUB, JOHN E., THIRUMALAI, DEVARAJAN · 2015 to 2022
$2.7MSoluble αSyn is a modulator of AD pathophysiologyRF1AG044342 · NIA · UNIVERSITY OF MINNESOTA · PI LESNE, SYLVAIN E. · 2019 to 2019
$2.7MRevealing Epistasis in Alzheimer DiseaseR01AG020135 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MARTIN, EDEN R. · 2002 to 2006
$2.7MMembrane interaction and disruption by the Alzheimer's amyloid-beta peptideR01AG048934 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAMAMOORTHY, AYYALUSAMY · 2016 to 2020
$2.0MKlotho and Neurodegenerative DiseaseR01NS092918 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBAL, DENA BOU · 2016 to 2020
$1.7MNCATS NIH HHS UL1 TR002014NIA NIH HHS R01 AG020135NIA NIH HHS R01 AG048934NIA NIH HHS R01 AG054025NIA NIH HHS R21 AG065693NIA NIH HHS RF1 AG044342NIA NIH HHS RF1 AG062135NIGMS NIH HHS R01 GM107703NIGMS NIH HHS R01 GM118560NIGMS NIH HHS R35 GM134864NINDS NIH HHS R01 NS092918NINDS NIH HHS R01 NS094557NINDS NIH HHS R56 NS113549
Abstract
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. Structural and dynamic characterization of all species along the pathways from monomers to fibrils is challenging by experimental and computational means because they involve intrinsically disordered proteins in most diseases. Yet understanding how amyloid species become toxic is the challenge in developing a treatment for these diseases. Here we review what computer,
Indexed as
alpha-SynucleinAlzheimer DiseaseAmyloidAmyloid beta-PeptidesAmyotrophic Lateral SclerosisAnimalsDiabetes Mellitus, Type 2HumansIslet Amyloid PolypeptideModels, MolecularNeurodegenerative DiseasesParkinson DiseaseProtein Aggregation, PathologicalProteostasis DeficienciesSuperoxide Dismutase-1tau Proteinsalpha-SynucleinAmyloidAmyloid beta-PeptidesIslet Amyloid PolypeptideSuperoxide Dismutase-1tau Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.