Evidence map›Paper›PMID 33543655›Full record

Trial reportIntegrative cancer therapies

A Randomized, Controlled, Parallel-Group, Trial on the Effects of Melatonin on Fatigue Associated with Breast Cancer and Its Adjuvant Treatments.

Abdolazim Sedighi Pashaki, Kamal Mohammadian, Saeid Afshar, Mohammad Hadi Gholami, Abbas Moradi, Seyed Alireza Javadinia, Zahra Keshtpour Amlashi

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 5 pooled it
2.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Melatonin in cancer treatment.The Cochrane database of systematic reviews · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Abdolazim Sedighi PashakiHamadan University of Medical Sciences, Hamadan, Iran.
Kamal MohammadianHamadan University of Medical Sciences, Hamadan, Iran.ORCID 0000-0003-4635-7366
Saeid AfsharHamadan University of Medical Sciences, Hamadan, Iran.
Mohammad Hadi GholamiMahdieh Radiotherapy Center, Hamadan, Iran.
Abbas MoradiHamadan University of Medical Sciences, Hamadan, Iran.
Seyed Alireza JavadiniaSabzevar University of Medical Sciences, Sabzevar, Iran.ORCID 0000-0003-2467-837X
Zahra Keshtpour AmlashiHamadan University of Medical Sciences, Hamadan, Iran.ORCID 0000-0001-7126-0393
Hamedan University of Medical Sciences · IRSabzevar University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFatigue associated with malignant conditions and their treatments is a disabling condition. This trial assessed the anti-fatigue effects of melatonin coadministration during adjuvant treatment of patients with the breast cancer. MATERIAL AND

methodsPatients with breast cancer were randomly assigned to receive melatonin or placebo during adjuvant chemotherapy and radiotherapy. Thirty-seven patients were randomly enrolled in each group. The mean ages of patients in the intervention and control groups were 50.47 ± 10.79 and 46.05 ± 10.55 years, respectively (

resultsThe BFI score was similar before the intervention in both groups, however, after the intervention, it was significantly lower in the melatonin group (

conclusionCoadministration of melatonin during adjuvant chemotherapy and radiotherapy of women with breast cancer decreased the levels of fatigue associated with the malignant condition and its treatments.

Indexed as

Breast NeoplasmsMelatoninAdultChemotherapy, AdjuvantFatigueFemaleHumansMiddle AgedQuality of LifeMelatoninadjuvant treatmentbreast cancerfatiguemelatonin

Identifiers

PMID33543655
PMCPMC7868453
OpenAlexW3128935748

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.