Evidence map›Paper›PMID 33543506›Full record

ArticleJournal of veterinary internal medicine2021

Symmetric dimethylarginine and creatinine concentrations in serum of healthy draft horses.

Harold C Schott, Lisanne R Gallant, Michael Coyne, Rachel Murphy, Julie Cross, Marilyn Strong-Townsend, Donald Szlosek, Maha Yerramilli, Jun Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Biomarkers of Kidney Disease in Horses: A Review of the Current Literature.Animals : an open access journal from MDPI · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. ECEIM consensus statement on equine kidney disease.Journal of veterinary internal medicine
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Harold C SchottDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.ORCID https://orcid.org/0000-0002-7728-5409
Lisanne R GallantDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Michael CoyneIDEXX Laboratories, Inc., Westbrook, Maine, USA.
Rachel MurphyIDEXX Laboratories, Inc., Westbrook, Maine, USA.
Julie CrossIDEXX Laboratories, Inc., Westbrook, Maine, USA.
Marilyn Strong-TownsendIDEXX Laboratories, Inc., Westbrook, Maine, USA.
Donald SzlosekIDEXX Laboratories, Inc., Westbrook, Maine, USA.
Maha YerramilliIDEXX Laboratories, Inc., Westbrook, Maine, USA.
Jun LiIDEXX Laboratories, Inc., Westbrook, Maine, USA.
IDEXX Laboratories (United States) · USAlbion Centre · AUMichigan State University · USNovartis (Switzerland) · CH

Funding

IDEXX Laboratories, IncMichigan State University College of Veterinary Medicine Endowed Research Funds
6 · The paper itself

Abstract

backgroundSymmetric dimethylarginine (SDMA) is considered a more sensitive indirect estimate of glomerular filtration rate (GFR) than creatinine (Cr). Symmetric dimethylarginine is not affected by sex or muscle mass in small animals.

objectivesTo validate a commercial SDMA immunoassay (IA) for equine serum; to compare SDMA and Cr in cohorts of draft horse breeds; and to assess effects of age, sex, and breed. ANIMALS: One hundred and sixty-five healthy draft horses (0.5-16 years), including 63 Percherons, 52 Clydesdales, and 50 Belgians.

methodsCross-sectional study. The SDMA IA was validated for equine serum by comparison to liquid chromatography-mass spectroscopy (LC-MS) results and other methods. Symmetric dimethylarginine and Cr were compared by analysis of variance and correlation analysis.

resultsMedian and 95% confidence intervals (CIs) for LC-MS (10.0 [9.4, 10.2] μg/dL) and IA (9.7 [9.5, 10.0] μg/dL) SDMA concentrations were strongly correlated (R = .74, P < .001). Symmetric dimethylarginine was lower (P < .01) in Percherons and Belgians, than in Clydesdales. Median values and 95% CI for Cr were 1.3 (1.2, 1.4), 1.4 (1.3, 1.5), and 1.4 (1.3, 1.5) mg/dL (P = .06) for Percherons, Clydesdales, and Belgians, respectively. Symmetric dimethylarginine was correlated to Cr (LC-MS, R = .60, P < .001; IA, R = .66, P < .001). There were no differences in SDMA or Cr between sexes and there were no correlations between age and SDMA or Cr. CONCLUSIONS AND CLINICAL IMPORTANCE: Although a significant breed effect on SDMA concentration was found, differences were small and all medians were <14 μg/dL, the cutoff value to support renal dysfunction in dogs and cats.

Indexed as

Cat DiseasesDog DiseasesHorse DiseasesRenal Insufficiency, ChronicAnimalsArginineBiomarkersCatsCreatinineCross-Sectional StudiesDogsHorsesArginineBiomarkersCreatininesymmetric dimethylarginineglomerular filtration ratelaboratory assessmentrenal diseaserenal functionurea

Identifiers

PMID33543506
PMCPMC7995414
OpenAlexW3127030887

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.