Evidence map›Paper›PMID 33543453›Full record

ArticleAdvances in experimental medicine and biology2021

Conventional Nanosized Drug Delivery Systems for Cancer Applications.

Cristian Vergallo, Muhammad Nadeem Hafeez, Dalila Iannotta, Hélder A Santos, Nicola D'Avanzo, Luciana Dini, Felisa Cilurzo, Massimo Fresta, Luisa Di Marzio, Celia Christian

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Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Nanocarriers for anticancer drugs: Challenges and perspectives.Saudi journal of biological sciences · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cristian Vergallo *Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, Italy.
Muhammad Nadeem Hafeez *Department of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, Italy.
Dalila IannottaDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, Italy.
Hélder A SantosFaculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Nicola D'AvanzoDepartment of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.
Luciana DiniDepartment of Biology and Biotechnology "Charles Darwin", University of Rome "Sapienza", Rome, Italy.
Felisa CilurzoDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, Italy.
Massimo FrestaDepartment of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.
Luisa Di MarzioDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, Italy.
Celia ChristianDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti, Italy. c.celia@unich.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical responses and tolerability of conventional nanocarriers (NCs) are sometimes different from those expected in anticancer therapy. Thus, new smart drug delivery systems (DDSs) with stimuli-responsive properties and novel materials have been developed. Several clinical trials demonstrated that these DDSs have better clinical therapeutic efficacy in the treatment of many cancers than free drugs. Composition of DDSs and their surface properties increase the specific targeting of therapeutics versus cancer cells, without affecting healthy tissues, and thus limiting their toxicity versus unspecific tissues. Herein, an extensive revision of literature on NCs used as DDSs for cancer applications has been performed using the available bibliographic databases.

Indexed as

NanoparticlesNeoplasmsDrug CarriersDrug Delivery SystemsHumansDrug CarriersActive targetingAnticancer therapyAptamersCarbon nanostructureColloidal nanoparticlesDendrimersDrug delivery systemsHyper-branched polymersLipid nanoparticlesLiposomesMetallic nanoparticlesNanocrystalPassive targetingPolymeric nanoparticlesTherapeutic proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.