ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2021
Major locus for spontaneous haploid genome doubling detected by a case-control GWAS in exotic maize germplasm.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- A two-stage screening approach integrated with GWAS for rare phenotypes such as spontaneous haploid genome doubling in maize.Frontiers in plant science · 2026Article
- Grading evaluation of haploid fertility restoration traits based on inception-ResNet in maize.Plant phenomics (Washington, D.C.) · 2025Article
- Genetic variation and heritability of haploid frailty in maize.Frontiers in plant science · 2025Article
- Dissecting the genetic variation of haploid frailty in maize for enhanced doubled haploid breeding.Frontiers in plant science · 2025Article
- Genes and genetics belong to maize haploid induction.Frontiers in plant science · 2025Review
- Fine mapping of major QTL qshgd1 for spontaneous haploid genome doubling in maize (Zea mays L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Cyto-swapping in maize by haploid induction with a cenh3 mutant.Nature plants · 2024Article
- Phenotypic and genome-wide association analyses for nitrogen use efficiency related traits in maize (Frontiers in plant science · 2023Article
- Genetic basis of maize maternal haploid induction beyondFrontiers in plant science · 2023Article
- Development of doubled haploid inducer lines facilitates selection of superior haploid inducers in maize.Frontiers in plant science · 2023Article
- Usefulness of temperate-adapted maize lines developed by doubled haploid and single-seed descent methods.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Protocols for In Vivo Doubled Haploid (DH) Technology in Maize Breeding: From Haploid Inducer Development to Haploid Genome Doubling.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A PARTHENOGENESIS allele from apomictic dandelion can induce egg cell division without fertilization in lettuce.Nature genetics · 2022Article
- Unravelling Rubber Tree Growth by Integrating GWAS and Biological Network-Based Approaches.Frontiers in plant science · 2021Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
key messageA major locus for spontaneous haploid genome doubling was detected by a case-control GWAS in an exotic maize germplasm. The combination of double haploid breeding method with this locus leads to segregation distortion on genomic regions of chromosome five. Temperate maize (Zea mays L.) breeding programs often rely on limited genetic diversity, which can be expanded by incorporating exotic germplasm. The aims of this study were to perform characterization of inbred lines derived from the tropical BS39 population using different breeding methods, to identify genomic regions showing segregation distortion in lines derived by the DH process using spontaneous haploid genome doubling (SHGD), and use case-control association mapping to identify loci controlling SHGD. Four different sets were used: BS39_DH and BS39_SSD were derived from the BS39 population by DH and single-seed descendent (SSD) methods, and BS39 × A427_DH and BS39 × A427_SSD from the cross between BS39 and A427. A total of 663 inbred lines were genotyped. The analyses of gene diversity and genetic differentiation for the DH sets provided evidence of the presence of a SHGD locus near the centromere of chromosome 5. The case-control GWAS for the DH set also pinpointed this locus. Haplotype sharing analysis showed almost 100% exclusive contribution of the A427 genome in the same region on chromosome 5 of BS39 × A427_DH, presumably due to an allele in this region affecting SHGD. This locus enables DH line production in exotic populations without colchicine or other artificial haploid genome doubling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.