ReviewMolecular human reproduction2021
Biophysical optimization of preimplantation embryo culture: what mechanics can offer ART.
Review in Molecular human reproduction, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Mechanical cues regulateMaterials today. Bio · 2026Article
- Association between laser-assisted hatching and subsequent blastocyst development in fresh day 3 cleavage-stage embryos: a retrospective cohort study using propensity score matching, generalized estimating equations, and time-sensitivity analyses.Frontiers in endocrinology · 2026Article
- Stage-specific machine learning prediction of cumulative live birth in women with diminished ovarian reserve.Frontiers in endocrinology · 2026Article
- Development and application of vibrating dynamic culture system for mouse oocytes and embryos.Frontiers in veterinary science · 2025Article
- Region-Specific Decellularization of Porcine Uterine Tube Extracellular Matrix: A New Approach for Reproductive Tissue-Engineering Applications.Biomimetics (Basel, Switzerland) · 2024Article
- Review
- A Review: Biomechanical Aspects of the Fallopian Tube Relevant to its Function in Fertility.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- The changing tide of human fertility.Human reproduction (Oxford, England) · 2022Article
- Oocyte Spontaneous Activation: An Overlooked Cellular Event That Impairs Female Fertility in Mammals.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Owing to the rise of ART and mounting reports of epigenetic modification associated with them, an understanding of optimal embryo culture conditions and reliable indicators of embryo quality are highly sought after. There is a growing body of evidence that mechanical biomarkers can rival embryo morphology as an early indicator of developmental potential and that biomimetic mechanical cues can promote healthy development in preimplantation embryos. This review will summarize studies that investigate the role of mechanics as both indicators and promoters of mammalian preimplantation embryo development and evaluate their potential for improving future embryo culture systems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.