Evidence map›Paper›PMID 33543129›Full record

ArticleBrain communications2020

Plasma glial fibrillary acidic protein and neurofilament light chain, but not tau, are biomarkers of sports-related mild traumatic brain injury.

Etienne Laverse, Tong Guo, Karl Zimmerman, Martha S Foiani, Bharat Velani, Philip Morrow, Ademola Adejuwon, Richard Bamford, Natasha Underwood, Jonathan George and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 44 citations in OpenAlex.

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  19. The Role of Clinical Assessment in the Era of Biomarkers.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 4 countries.

Etienne LaverseDepartment of Clinical and Movement Neurosciences, UCL Institute of Neurology, Queen Square, UK.ORCID 0000-0003-4302-9252
Tong GuoDepartment of Clinical and Movement Neurosciences, UCL Institute of Neurology, Queen Square, UK.
Karl ZimmermanDivision of Brain Sciences, Department of Medicine, Imperial College London, London, UK.
Martha S FoianiDepartment of Neurodegenerative Disease, UK Dementia Research Institute at UCL, UCL Institute of Neurology, University College London, London, UK.
Bharat VelaniDepartment of Clinical and Movement Neurosciences, UCL Institute of Neurology, Queen Square, UK.
Philip MorrowSaracens Rugby Club, UK.
Ademola AdejuwonEaling Trailfinders Rugby Club, London, UK.
Richard BamfordSaracens Rugby Club, UK.
Natasha UnderwoodSaracens Rugby Club, UK.
Jonathan GeorgeSaracens Rugby Club, UK.
Daniel BrookeEaling Trailfinders Rugby Club, London, UK.
Karen O'BrienLondon Scottish Rugby Club, UK.
Matthew J CrossPremiership Rugby, Twickenham, London, UK.
Simon P T KempRugby Football Union, Twickenham, London, UK.ORCID 0000-0002-3250-2713
Amanda J HeslegraveDepartment of Neurodegenerative Disease, UK Dementia Research Institute at UCL, UCL Institute of Neurology, University College London, London, UK.
John HardyDepartment of Neurodegenerative Disease, UK Dementia Research Institute at UCL, UCL Institute of Neurology, University College London, London, UK.
David J SharpDivision of Brain Sciences, Department of Medicine, Imperial College London, London, UK.
Henrik ZetterbergDepartment of Neurodegenerative Disease, UK Dementia Research Institute at UCL, UCL Institute of Neurology, University College London, London, UK.
Huw R MorrisDepartment of Clinical and Movement Neurosciences, UCL Institute of Neurology, Queen Square, UK.ORCID 0000-0002-5473-3774
National Hospital for Neurology and Neurosurgery · GBImperial College London · GBTrailfinders Travel Clinic · GBUK Dementia Research Institute · GBHong Kong University of Science and Technology · HKSahlgrenska University Hospital · SEThe Football Association · GB

Funding

Department of Health NIHR-RP-011-048Wellcome Trust
6 · The paper itself

Abstract

Mild traumatic brain injury is a relatively common event in contact sports and there is increasing interest in the long-term neurocognitive effects. The diagnosis largely relies on symptom reporting and there is a need for objective tools to aid diagnosis and prognosis. There are recent reports that blood biomarkers could potentially help triage patients with suspected injury and normal CT findings. We have measured plasma concentrations of glial and neuronal proteins and explored their potential in the assessment of mild traumatic brain injury in contact sport. We recruited a prospective cohort of active male rugby players, who had pre-season baseline plasma sampling. From this prospective cohort, we recruited 25 players diagnosed with mild traumatic brain injury. We sampled post-match rugby players without head injuries as post-match controls. We measured plasma neurofilament light chain, tau and glial fibrillary acidic protein levels using ultrasensitive single molecule array technology. The data were analysed at the group and individual player level. Plasma glial fibrillary acidic protein concentration was significantly increased 1-h post-injury in mild traumatic brain injury cases compared to the non-injured group (

Indexed as

biomarkersconcussionGFAPmild-TBINFL

Identifiers

PMID33543129
PMCPMC7846133
OpenAlexW3084438998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.