ArticleBrain communications2020
The effect of alcohol withdrawal syndrome severity on sleep, brain and cognition.
Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- The Impact of Physical Activity on Sleep in Alcohol Users: A Systematic Review.Addiction biology · 2025Pooled it
- Objective and subjective measurement of sleep in people who use substances: Emerging evidence and recommendations from a systematic review.Journal of sleep research · 2025Pooled it
- Kava (Nutrients · 2026Review
- Cerebellar hypermetabolism disrupts fronto-cerebellar resting-state functional connectivity and associated executive compensation.Translational psychiatry · 2026Article
- Physical activity and sleep disturbances in individuals with alcohol use disorder: protocol of the APhysOH pilot study for a randomized controlled trial.Addiction science & clinical practice · 2026Article
- Sleep disturbance is associated with greater subjective and neural negative emotionality in people with alcohol use disorder.Drug and alcohol dependence · 2026Article
- Sleep alterations in substance use disorders: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- Network characteristics of comorbid symptoms in alcohol use disorder.Annals of medicine · 2025Article
- Investigation and analysis of factors related to sleep conditions during the acute withdrawal period of alcohol use disorder.Frontiers in psychiatry · 2025Article
- Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory.Quantitative imaging in medicine and surgery · 2024Article
- Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence.Brain imaging and behavior · 2024Article
- Compensation patterns and altered functional connectivity in alcohol use disorder with and without Korsakoff's syndrome.Brain communications · 2024Article
- Distinct Sleep Alterations in Alcohol Use Disorder Patients with and without Korsakoff's Syndrome: Relationship with Episodic Memory.Journal of clinical medicine · 2023Article
- Metabotropic glutamate receptor function and regulation of sleep-wake cycles.International review of neurobiology · 2023Article
- GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential.Frontiers in neural circuits · 2023Review
- Neurocognitive Recovery in Abstinent Patients with Alcohol Use Disorder: A Scoping Review for Associated Factors.Neuropsychiatric disease and treatment · 2023Article
- Brain glutamate and sleep efficiency associations following a ketogenic diet intervention in individuals with Alcohol Use Disorder.Drug and alcohol dependence reports · 2022Article
- Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment?Antioxidants (Basel, Switzerland) · 2022Review
- Poor subjective sleep predicts compromised quality of life but not cognitive impairment in abstinent individuals with Alcohol Use Disorder.Alcohol (Fayetteville, N.Y.) · 2022Article
- Effect of detoxification on N3 sleep correlates with brain functional but not structural changes in alcohol use disorder.Drug and alcohol dependence · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In alcohol use disorder, drinking cessation is frequently associated with an alcohol withdrawal syndrome. Early in abstinence (within the first 2 months after drinking cessation), when patients do not exhibit physical signs of alcohol withdrawal syndrome anymore (such as nausea, tremor or anxiety), studies report various brain, sleep and cognitive alterations, highly heterogeneous from one patient to another. While the acute neurotoxicity of alcohol withdrawal syndrome is well-known, its contribution to structural brain alterations, sleep disturbances and neuropsychological deficits observed early in abstinence has never been investigated and is addressed in this study. We included 54 alcohol use disorder patients early in abstinence (from 4 to 21 days of sobriety) and 50 healthy controls. When acute physical signs of alcohol withdrawal syndrome were no longer present, patients performed a detailed neuropsychological assessment, a T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.