ArticleBrain communications2020
Cerebral atrophy in amyotrophic lateral sclerosis parallels the pathological distribution of TDP43.
Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis.Journal of neurochemistry · 2026Review
- Quantification of amyotrophic lateral sclerosis (ALS) disease accumulation with T1-weighted high-resolution magnetic resonance imaging: validation in an independent cohort.Journal of neurology · 2026Article
- Brain Folding Trajectories in Amyotrophic Lateral Sclerosis.Human brain mapping · 2026Article
- Ten years of using the APACS test: a multistudy cross-diagnostic analysis of pragmatic profiles and their relationship with Theory of Mind.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Network spreading and local biological vulnerability in amyotrophic lateral sclerosis.Communications biology · 2025Article
- Distinct Longitudinal Clinical-Neuroanatomical Trajectories in Parkinson's Disease Clinical Subtypes: Insight toward Precision Medicine.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Mapping motor and extra-motor gray and white matter changes in ALS: a comprehensive review of MRI insights.Neuroradiology · 2025Review
- Regional Cerebral Atrophy Contributes to Personalized Survival Prediction in Amyotrophic Lateral Sclerosis: A Multicentre, Machine Learning, Deformation-Based Morphometry Study.Annals of neurology · 2025Article
- Disentangling the effect of sex from brain size on brain organization and cognitive functioning.GeroScience · 2025Article
- Implications of perivascular spaces in amyotrophic lateral sclerosis: clinical significance and structural correlation.Brain communications · 2025Article
- Apathy progression is associated with brain atrophy and white matter damage in Parkinson's disease.Brain communications · 2025Article
- A meaningful prediction of functional decline in amyotrophic lateral sclerosis based on multi-event survival analysis.PloS one · 2025Article
- Longevity of a Brain-Computer Interface for Amyotrophic Lateral Sclerosis.The New England journal of medicine · 2024Article
- Review
- Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions.eLife · 2024Article
- Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis.Frontiers in neuroscience · 2024Article
- Evidence based on Mendelian randomization and colocalization analysis strengthens causal relationships between structural changes in specific brain regions and risk of amyotrophic lateral sclerosis.Frontiers in neuroscience · 2024Article
- Review
- Brain imaging signatures in amyotrophic lateral sclerosis: Correlation with peripheral motor degeneration.Annals of clinical and translational neurology · 2023Article
- MRI Clustering Reveals Three ALS Subtypes With Unique Neurodegeneration Patterns.Annals of neurology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by a preferential involvement of both upper and lower motor neurons. Evidence from neuroimaging and post-mortem studies confirms additional involvement of brain regions extending beyond the motor cortex. The aim of this study was to assess the extent of cerebral disease in amyotrophic lateral sclerosis cross-sectionally and longitudinally and to compare the findings with a recently proposed disease-staging model of amyotrophic lateral sclerosis pathology. Deformation-based morphometry was used to identify the patterns of brain atrophy associated with amyotrophic lateral sclerosis and to assess their relationship with clinical symptoms. Longitudinal T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.