Evidence map›Paper›PMID 33543056›Full record

ArticleArchives of rehabilitation research and clinical translation2019

Translingual Neurostimulation for the Treatment of Chronic Symptoms Due to Mild-to-Moderate Traumatic Brain Injury.

Mitchell Tyler, Kim Skinner, Vivek Prabhakaran, Kurt Kaczmarek, Yuri Danilov

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of rehabilitation research and clinical translation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02158494 (Cranial Nerve Noninvasive Neuromodulation Using the PoNS for Treatment of Symptoms Due to Mild or Moderate Traumatic Brain Injury), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02158494 nacompletednot on this map

Cranial Nerve Noninvasive Neuromodulation Using the PoNS for Treatment of Symptoms Due to Mild or Moderate Traumatic Brain Injury

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2014 to 2017Enrolled44ConditionsBrain Injuries, TraumaticArmsBalance and Gait Training using neurostimulation modulation., Sham Device
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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  11. Translingual neural stimulation affects resting-state functional connectivity in mild-moderate traumatic brain injury.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mitchell TylerDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin.
Kim SkinnerDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.
Vivek PrabhakaranDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.
Kurt KaczmarekDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.
Yuri DanilovDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.
University of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the efficacy of high- and low-frequency noninvasive translingual neurostimulation (TLNS) plus targeted physical therapy (PT) for treating chronic balance and gait deficits due to mild-to-moderate traumatic brain injury (mmTBI).

designParticipants were randomized 1:1 in a 26-week double-blind phase 1/2 study (NCT02158494) with 3 consecutive treatment stages: in-clinic, at-home, and no treatment. Arms were high-frequency pulse (HFP) and low-frequency pulse (LFP) TLNS.

settingTLNS plus PT training was initiated in-clinic and then continued at home.

participantsParticipants (N=44; 18-65y) from across the United States were randomized into the HFP and LFP (each plus PT) arms. Forty-three participants (28 women, 15 men) completed at least 1 stage of the study. Enrollment requirements included an mmTBI ≥1 year prior to screening, balance disorder due to mmTBI, a plateau in recovery with current PT, and a Sensory Organization Test (SOT) score ≥16 points below normal.

interventionsParticipants received TLNS (HFP or LFP) plus PT for a total of 14 weeks (2 in-clinic and 12 at home), twice daily, followed by 12 weeks without treatment.

main outcome measuresThe primary endpoint was change in SOT composite score from baseline to week 14. Secondary variables (eg, Dynamic Gait Index [DGI], 6-minute walk test [6MWT]) were also collected.

resultsBoth arms had a significant (

conclusionsBoth the HFP+PT and LFP+PT groups had significantly improved balance scores, and outcomes were sustained for 12 weeks after discontinuing TLNS treatment. Results between arms did not significantly differ from each other. Whether the 2 dosages are equally effective or whether improvements are because of provision of PT cannot be conclusively established at this time.

Indexed as

6MWT, 6-minute walk testAE, adverse eventANOVA, analysis of varianceBalanceDGI, Dynamic Gait IndexFacial nerveGaitHFP, high-frequency pulseITP, in-clinic training programLFP, low-frequency pulsemmTBI, mild-to-moderate traumatic brain injuryNeurostimulationPoNS, portable neuromodulation stimulatorPSQI, Pittsburgh Sleep Quality IndexPT, physical therapyRehabilitationSOT, Sensory Organization TestTBI, traumatic brain injuryTLNS, translingual neurostimulationTrigeminal nerve

Identifiers

PMID33543056
PMCPMC7853385
OpenAlexW2976079458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.