Evidence map›Paper›PMID 33543027›Full record

ArticleMatrix biology plus2020

Induction of heparanase via IL-10 correlates with a high infiltration of CD163+ M2-type tumor-associated macrophages in inflammatory breast carcinomas.

Mennatullah El-Nadi, Hebatallah Hassan, Moshira Ezzat Saleh, Eyyad Nassar, Yahia Mahmoud Ismail, Mahmoud Amer, Burkhard Greve, Martin Götte, Mohamed El-Shinawi, Sherif Abdelaziz Ibrahim

Open access · goldAbstract read
In one paragraph

Article in Matrix biology plus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. The Heparanase Regulatory Network in Health and Disease.International journal of molecular sciences · 2021
    Review
  7. Article
  8. Article
  9. Fibroblasts: The arbiters of extracellular matrix remodeling.Matrix biology : journal of the International Society for Matrix Biology · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Mennatullah El-NadiDepartment of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Hebatallah HassanDepartment of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Moshira Ezzat SalehDepartment of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Eyyad NassarDepartment of Gynecology and Obstetrics, Münster University Hospital, Münster, Germany.
Yahia Mahmoud IsmailMedical Oncology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Mahmoud AmerDepartment of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Burkhard GreveDepartment of Radiotherapy-Radiooncology, University Hospital Münster, Münster, Germany.
Martin GötteDepartment of Gynecology and Obstetrics, Münster University Hospital, Münster, Germany.
Mohamed El-ShinawiDepartment of General Surgery, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
Sherif Abdelaziz IbrahimDepartment of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Cairo University · EGUniversity Hospital Münster · DEAin Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory breast cancer (IBC) is the most aggressive and lethal form of breast cancer, characterized by a high infiltration of tumor-associated macrophages and poor prognosis. To identify new biomarkers and to elucidate the molecular mechanisms underlying IBC pathogenesis, we investigated the expression pattern of heparanase (HPSE) and its activator cathepsin L (CTSL). First, we quantitated the

Indexed as

Cathepsin LCD163+ M2-type tumor-associated macrophagesCTSL, cathepsin LECM, extracellular matrixER, estrogen receptorFFPE, Formalin-Fixed Paraffin-EmbeddedHeparanaseHER-2, human epidermal growth factor receptor-2HPSE, heparanaseHSPGs, heparan sulfate proteoglycansIBC, inflammatory breast cancer;IL-10Inflammatory breast cancerInvasionIRB, Institutional Review BoardMMP2, matrix metalloproteinase2MTT, 3-(4,5-dimethyl-2-yl)-2,5-diphenyltetrazolium bromideOGT 2115, 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acidPR, progesterone receptorqPCR, quantitative real-time PCRrh IL-10, recombinant human interleukin-10TAMs, tumor-associated macrophagesTNF-α, tumor necrosis factor-αTN, triple negativeTriple negative subtype

Identifiers

PMID33543027
PMCPMC7852308
OpenAlexW3010289494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.