Evidence map›Paper›PMID 33543002›Full record

ArticleMatrix biology plus2019

CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets.

Henrik J Jürgensen, Lakmali M Silva, Oliver Krigslund, Sander van Putten, Daniel H Madsen, Niels Behrendt, Lars H Engelholm, Thomas H Bugge

Open access · goldAbstract read
In one paragraph

Article in Matrix biology plus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 25 citations in OpenAlex.

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  9. A macrophage-collagen fragment axis mediates subcutaneous adipose tissue remodeling in mice.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Henrik J JürgensenProteases and Tissue Remodeling Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Lakmali M SilvaProteases and Tissue Remodeling Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Oliver KrigslundProteases and Tissue Remodeling Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Sander van PuttenFinsen Laboratory, Rigshospitalet/BRIC, University of Copenhagen, Ole Maaloesvej 5, DK-2200 Copenhagen N, Denmark.
Daniel H MadsenFinsen Laboratory, Rigshospitalet/BRIC, University of Copenhagen, Ole Maaloesvej 5, DK-2200 Copenhagen N, Denmark.
Niels BehrendtFinsen Laboratory, Rigshospitalet/BRIC, University of Copenhagen, Ole Maaloesvej 5, DK-2200 Copenhagen N, Denmark.
Lars H EngelholmFinsen Laboratory, Rigshospitalet/BRIC, University of Copenhagen, Ole Maaloesvej 5, DK-2200 Copenhagen N, Denmark.
Thomas H BuggeProteases and Tissue Remodeling Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Rigshospitalet · DKNational Institute of Dental and Craniofacial Research · USUniversity of Copenhagen · DKNational Institutes of Health · US

Funding

NIDCR DIR Scientific Cores (Combined Technical Research Core)ZICDE000729 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ABSHARI, MEHRNOOSH · 2009 to 2025
$31.7M
Intramural NIH HHS ZIC DE000729
6 · The paper itself

Abstract

Macrophage plasticity, cellular origin, and phenotypic heterogeneity are perpetual challenges for studies addressing the biology of this pivotal immune cell in development, homeostasis, and tissue remodeling/repair. Consequently, a myriad of macrophage subtypes has been described in these contexts. To facilitate the identification of functional macrophage subtypes

Indexed as

AF, Alexa FluorCCL2/MCP-1, chemokine (C-C motif) ligand 2/monocyte chemoattractant protein 1CCR2, C-C chemokine receptor type 2CEMS, collagen-endocytosing macrophagesCollagen degradationECM, extracellular matrixExtracellular matrix endocytosisFEMS, fibrin-endocytosing macrophagesFibrin degradationFMO, fluorescence minus oneGM-CSF, Granulocyte Macrophage-Colony Stimulating FactorGM-CSFR, GM-CSF ReceptorIL4Ra, IL4 Receptor aIL, InterleukinInterleukin-13Mannose receptor/CD206M-CSF, Macrophage-Colony Stimulating FactorMR, mannose receptor/CD206Plg, plasminogenRFP, red fluorescent proteinuPARAP/Endo180uPARAP, urokinase plasminogen activator receptor associated protein/Endo180

Identifiers

PMID33543002
PMCPMC7852312
OpenAlexW2923532320

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.