ArticleExtreme Mechanics Letters2021
Curvature-Regulated Lipid Membrane Softening of Nano-Vesicles.
Article in Extreme Mechanics Letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Acoustic characterization of shell and size-engineered submicron contrast agents using attenuation measurements.Ultrasonics sonochemistry · 2026Article
- Saddle curvature association of nsP1 facilitates the replication complex assembly of Chikungunya virus in cells.Nature communications · 2025Article
- Mechanical property estimation of sarcoma-relevant extracellular vesicles using transmission electron microscopy.Journal of extracellular biology · 2024Article
- Unraveling How Antimicrobial Lipid Mixtures Disrupt Virus-Mimicking Lipid Vesicles: A QCM-D Study.Biomimetics (Basel, Switzerland) · 2024Article
- Understanding the Mechanical Properties of Ultradeformable Liposomes Using Molecular Dynamics Simulations.The journal of physical chemistry. B · 2023Article
- Molecular Dynamics Simulations of Curved Lipid Membranes.International journal of molecular sciences · 2022Review
- Effection of Lactic Acid Dissociation on Swelling-Based Short-Chain Fatty Acid Vesicles Nano-Delivery.Foods (Basel, Switzerland) · 2022Article
- Potentiation of plant defense by bacterial outer membrane vesicles is mediated by membrane nanodomains.The Plant cell · 2022Article
- Site-Specific Peroxidation Modulates Lipid Bilayer Mechanics.Extreme Mechanics Letters · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The physico-mechanical properties of nanoscale lipid vesicles (e.g., natural nano-vesicles and artificial nano-liposomes) dictate their interaction with biological systems. Understanding the interplay between vesicle size and stiffness is critical to both the understanding of the biological functions of natural nano-vesicles and the optimization of nano-vesicle-based diagnostics and therapeutics. It has been predicted that, when vesicle size is comparable to its membrane thickness, the effective bending stiffness of the vesicle increases dramatically due to both the entropic effect as a result of reduced thermal undulation and the nonlinear curvature elasticity effect. Through systematic molecular dynamics simulations, we show that the vesicle membrane thins and softens with the decrease in vesicle size, which effectively counteracts the stiffening effects as already mentioned. Our simulations indicate that the softening of nano-vesicles results from a change in the bilayer's interior structure - a decrease in lipid packing order - as the membrane curvature increases. Our work thus leads to a more complete physical framework to understand the physico-mechanical properties of nanoscale lipid vesicles, paving the way to further advances in the biophysics of nano-vesicles and their biomedical applications.
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Registered trials
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