Evidence map›Paper›PMID 33542711›Full record

ArticleFrontiers in immunology2020

CD4 Inhibits Helper T Cell Activation at Lower Affinity Threshold for Full-Length T Cell Receptors Than Single Chain Signaling Constructs.

Deborah K Johnson, Wyatt Magoffin, Sheldon J Myers, Jordan G Finnell, John C Hancock, Taylor S Orton, Stephen P Persaud, Kenneth A Christensen, K Scott Weber

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Deborah K JohnsonDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Wyatt MagoffinDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Sheldon J MyersDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Jordan G FinnellDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, United States.
John C HancockDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Taylor S OrtonDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Stephen P PersaudDivision of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, United States.
Kenneth A ChristensenDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, United States.
K Scott WeberDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Brigham Young University · USWashington University in St. Louis · US

Funding

The role of antigenic strength in the primary and memory responses of pathogen spR15AI107753 · NIAID · BRIGHAM YOUNG UNIVERSITY · PI WEBER, K. SCOTT · 2013 to 2013
$449k
NIAID NIH HHS R15 AI107753
6 · The paper itself

Abstract

CD4

Indexed as

Lymphocyte ActivationModels, ImmunologicalAnimalsAntigens, NeoplasmCD4 AntigensHistocompatibility Antigens Class IIHybridomasImmunotherapy, AdoptiveInterleukin-2Lymphocyte Specific Protein Tyrosine Kinase p56(lck)MiceMice, Inbred C57BLMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaReceptors, Chimeric AntigenSignal TransductionAntigens, NeoplasmCD4 AntigensHistocompatibility Antigens Class IIInterleukin-2Lymphocyte Specific Protein Tyrosine Kinase p56(lck)Receptors, Antigen, T-Cell, alpha-betaReceptors, Chimeric AntigenaffinityCD4chimeric antigen receptorhelper T cellLckT cell receptor

Identifiers

PMID33542711
PMCPMC7851051
OpenAlexW3125841175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.