Evidence map›Paper›PMID 33542704›Full record

ArticleFrontiers in endocrinology2020

Exposure to Bisphenol A Analogs and the Thyroid Function and Volume in Women of Reproductive Age-Cross-Sectional Study.

Justyna Milczarek-Banach, Dominik Rachoń, Tomasz Bednarczuk, Katarzyna Myśliwiec-Czajka, Andrzej Wasik, Piotr Miśkiewicz

Open access · goldAbstract readClinical Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Justyna Milczarek-BanachDepartment of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Dominik RachońDepartment of Clinical and Experimental Endocrinology, Medical University of Gdańsk, Gdańsk, Poland.
Tomasz BednarczukDepartment of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Katarzyna Myśliwiec-CzajkaDepartment of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Andrzej WasikDepartment of Analytical Chemistry, Chemical Faculty, Gdańsk University of Technology, Gdańsk, Poland.
Piotr MiśkiewiczDepartment of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Medical University of Warsaw · PLGdańsk Medical University · PLGdańsk University of Technology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bisphenols (BPs) are commonly known plastifiers that are widely used in industry. The knowledge about the impact of BPs on thyroid function is scarce. Proper thyroid functioning is especially important for women of reproductive age, as hypothyroidism affects fertility, pregnancy outcomes and the offspring. There are no studies analyzing the influence of BPs on thyroid function and volume in non-pregnant young women. The aim of this cross-sectional study was to evaluate the relationship between bisphenol A and its 10 analogs (BPS, BPC, BPE, BPF, BPG, BPM, BPP, BPZ, BPFL, and BPBP) on thyroid function and volume in women of reproductive age. Inclusion criteria were: female sex, age 18-40 years. Exclusion criteria were history of any thyroid disease, pharmacotherapy influencing thyroid function, pregnancy or puerperium, and diagnosis of autoimmune thyroid disease during this study. Venous blood was drawn for measurement of thyrotropin (TSH), free thyroxine, thyroid peroxidase antibodies, thyroglobulin antibodies, BPs. Urine samples were analyzed for: ioduria and BPs. Ultrasound examination of thyroid gland was performed. One hundred eighty participants were included into the study. A negative correlation was found between urine BPC and the thyroid volume (R = -0.258; p = 0.0005). Patients with detected urine BPC presented smaller thyroid glands than those with not-detected urine BPC (p = 0.0008). A positive correlation was found between TSH and urine BPC (R = 0.228; p = 0.002). Patients with detected urine BPC presented higher concentrations of TSH versus those with not-detected urine BPC (p = 0.003). There were no relationships between any of serum BPs as well as the other urine BPs and thyroid function and its volume. The only BP that demonstrated the relationship between thyroid function and its volume was BPC, probably because of its chemical structure that most resembles thyroxine. Exposure to this BP may result in the development of hypothyroidism that could have a negative impact on pregnancy and the offspring.

Indexed as

AdolescentAdultBenzhydryl CompoundsBisphenol A CompoundsBisphenolsCross-Sectional StudiesDichloroethylenesDietary ExposureEstrogens, Non-SteroidalFemaleHumansHypothyroidismInhalation ExposurePhenolsPolandReproduction1,1-bis(4-hydroxyphenyl)-2,2-dichloroethyleneBenzhydryl Compoundsbisphenol ABisphenol A CompoundsBisphenolsDichloroethylenesEstrogens, Non-SteroidalPhenolsThyrotropinThyroxinebisphenolchemicalsendocrine disruptorshypothyroidismpregnancyreproductionthyroid functionthyroid volume

Identifiers

PMID33542704
PMCPMC7851079
OpenAlexW3121133320

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.