ArticleFrontiers in physiology2020
Transdermal Estrogen Therapy Improves Gains in Skeletal Muscle Mass After 12 Weeks of Resistance Training in Early Postmenopausal Women.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Impact of aerobic training on body composition profiles among postmenopausal women with overweight or obesity: a systematic review and dose-response meta-analysis.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Cross-education of lower limb muscle strength following resistance exercise training in males and females: A systematic review and meta-analysis.Experimental physiology · 2026Pooled it
- Age-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- The Effect of Hormonal Contraceptive Use on Skeletal Muscle Hypertrophy, Power and Strength Adaptations to Resistance Exercise Training: A Systematic Review and Multilevel Meta-analysis.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Menstrual cycle hormones and oral contraceptives: a multimethod systems physiology-based review of their impact on key aspects of female physiology.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Pooled it
- Influence of protein source (cricket, pea, whey) on amino acid bioavailability and activation of the mTORC1 signaling pathway after resistance exercise in healthy young males.European journal of nutrition · 2023Trial
- Effects of transdermal estrogen therapy on satellite cell number and molecular markers for muscle hypertrophy in response to resistance training in early postmenopausal women.European journal of applied physiology · 2023Trial
- Shatavari Supplementation in Postmenopausal Women Improves Handgrip Strength and IncreasesNutrients · 2021Trial
- From Myotubes to Skeletal Muscle:Cells · 2026Article
- Sex differences in potassium regulation: evidence, molecular mechanisms and clinical implications.Biology of sex differences · 2026Review
- Estrogen in skeletal muscle: metabolism, mechanisms, and exercise-induced changes.Journal of endocrinological investigation · 2026Review
- Menopause, Female Sex Hormones, Skeletal Muscle Mass and Muscle Protein Turnover in Humans.Journal of cachexia, sarcopenia and muscle · 2026Review
- Functional and muscle recovery after critical illness: current and future nutritional, physical and metabolic strategies.Annals of intensive care · 2026Review
- Integrated muscle protein synthesis during disuse and rehabilitation in late-midlife adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Enhanced Acute Muscle Activation in ALS Patients Following Liposomal Curcumin, Resveratrol, and Dutasteride Administration.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Postexercise myofibrillar protein synthesis rates do not differ following 1.5 g essential amino acids compared with 15 and 20 g of whey protein in young females.American journal of physiology. Endocrinology and metabolism · 2025Article
- Sexual dimorphisms in skeletal muscle: current concepts and research horizons.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- Interaction of estradiol and vitamin D with low skeletal muscle mass among middle-aged and elderly women.BMC women's health · 2023Article
- Handgrip Strength and Muscle Quality: Results from the National Health and Nutrition Examination Survey Database.Journal of clinical medicine · 2023Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextWomen show an accelerated loss of muscle mass around menopause, possibly related to the decline in estrogen. Furthermore, the anabolic response to resistance exercise seems to be hampered in postmenopausal women.
objectiveWe aimed to test the hypothesis that transdermal estrogen therapy (ET) amplifies the skeletal muscle response to resistance training in early postmenopausal women.
designA double-blinded randomized controlled study.
settingDepartment of Public Health, Aarhus University, Denmark.
participantsThirty-one healthy, untrained postmenopausal women no more than 5 years past menopause.
interventionsSupervised resistance training with placebo (PLC,
main outcome measuresThe primary outcome parameter was a cross-sectional area of quadriceps femoris measured by magnetic resonance imaging, and secondary parameters were fat-free mass (dual-energy X-ray absorptiometry), muscle strength, and functional tests.
resultsThe increase in muscle cross-sectional area was significantly greater in the ET group (7.9%) compared with the PLC group (3.9%) (
conclusionThe use of transdermal ET enhanced the increase in muscle mass in response to 12 weeks of progressive resistance training in early postmenopausal women.
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