Evidence map›Paper›PMID 33542591›Full record

ArticleSynlett : accounts and rapid communications in synthetic organic chemistry2020

Rational Design of New Dihydrobenzooxophosphole-Based Lewis Base Organocatalysts.

Bo Qu, Lalith P Samankumara, Anjan Saha, Mac G Schumer, Zhengxu S Han, Nizar Haddad, Carl A Busacca, Nathan K Yee, Marisa C Kozlowski, Jinghua J Song and 1 more

Abstract read
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In one paragraph

Article in Synlett : accounts and rapid communications in synthetic organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bo QuChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA.
Lalith P SamankumaraChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA.
Anjan SahaChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA.
Mac G SchumerDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Zhengxu S HanChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA.
Nizar HaddadChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA.
Carl A BusaccaChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA.
Nathan K YeeChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA.
Marisa C KozlowskiDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Jinghua J SongChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA.
Chris H SenanayakeChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA.

Funding

Computation and Development of New, Enabling Synthetic MethodsR35GM131902 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Marisa C Kozlowski · 2019 to 2026
$4.5M
Computational Methods for Selective CatalysisR01GM087605 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KOZLOWSKI, MARISA C · 2010 to 2019
$2.4M
NIGMS NIH HHS R01 GM087605NIGMS NIH HHS R35 GM131902
6 · The paper itself

Abstract

A series of new dihydrobenzooxophosphole-based Lewis Base organocatalysts were designed and synthesized. They are demonstrated effective in trichlorosilane-mediated stereoselective conjugate reductions of C=C bonds. DFT calculations reveal that the strong hydrogen bond between the amide linker and the chloride on silicon in the transition state contributes to the high reactivity of the catalyst

Indexed as

Chiral Lewis BaseEnone ReductionHydrogen BondingOrganocatalystP(O)NNP(O)

Identifiers

PMID33542591
PMCPMC7853668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.