Evidence map›Paper›PMID 33542565›Full record

ArticleIndian journal of anaesthesia2020

Perioperative factors predicting delayed enteral resumption and hospital length of stay in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: Retrospective cohort analysis from a single centre in India.

Kalpana Balakrishnan, Nivedhyaa Srinivasaraghavan, Meenakshi V Venketeswaran, Thendral Ramasamy, Ramakrishnan A Seshadri, E Hemanth Raj

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Article in Indian journal of anaesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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3 · Its place in the literature

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5 citing papers in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Kalpana BalakrishnanDepartment of Anaesthesiology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.
Nivedhyaa SrinivasaraghavanDepartment of Anaesthesiology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.
Meenakshi V VenketeswaranDepartment of Anaesthesiology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.
Thendral RamasamyDepartment of Anaesthesiology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.
Ramakrishnan A SeshadriDepartment of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.
E Hemanth RajDepartment of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsCytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is an extensive procedure associated with significant morbidity, delay in return of gastrointestinal function and discharge from hospital. Our aim was to assess perioperative factors influencing enteral resumption (ER) and length of stay in the hospital (LOS) in CRS-HIPEC.

methodsA retrospective analysis was conducted in a major tertiary cancer centre. Sixty-five patients who underwent CRS-HIPEC between July 2014 and March 2019 were included in the study. The perioperative data were collected from patient records. The primary outcome measure was day of oral resumption of 500 ml of clear fluids and secondary outcome was the LOS. Univariate and multivariate logistic regression analysis was done for the various continuous and categorical perioperative variables for both ER and LOS to elicit the magnitude of risk for both outcomes.

resultsUnivariate logistic regression revealed that peritoneal carcinomatosis index score (PCI), duration of surgery, blood loss and postoperative ventilation influenced both ER and LOS. Serum albumin, plasma usage and total peritonectomy affected only the LOS but not ER. Multivariate analysis showed that duration of surgery (

conclusionCRS-HIPEC is an extensive surgery and multiple factors are associated with ER; of these, duration of surgery and intraoperative fluid therapy are significant factors. Low serum albumin and prolonged postoperative ventilation are associated with increased LOS.

Indexed as

Cytoreductive surgeryhyperthermic intra-peritoneal chemotherapylength of staylogistic regressionserum albumin

Identifiers

PMID33542565
PMCPMC7852446

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